Pharmacology & ToxicologybioRxiv
Mechanistic insights into volatile anesthetic modulation of K2P channels
A. Wague, T. T. Joseph, K. A. Woll…·P. M. Riegelhaupt
This study identifies a volatile anesthetic binding site in TREK1 K2P channels and shows its role in modulating channel activity through molecular dynamics and mutagenesis.
DOI 10.7554/elife.59839