Author

C. M. Nimigean

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:fungi (other)· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Accardi· 1 shared A. Di Lorenzo· 1 shared A. Raczkowski· 1 shared A. Tong· 1 shared A. Wague· 1 shared B. A. Garcia· 1 shared B. Carragher· 1 shared B. Malone· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperBiochemistry

A. Accardi

Mutual co-authors in cluster

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4 papers

Recent·Most cited

BiophysicsMicroscopy and MicroanalysisPeer-reviewedJul 30, 2020

Time-resolved cryoEM using Spotiton

V. P. Dandey, W. C. Budell, H. Wei…·B. Carragher

The paper introduces a method for preparing cryoEM grids to study short-lived molecular states by rapidly dispensing sample drops and vitrifying them.

DOI 10.1017/s1431927620014245

cryo-EMexperimental assay

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivJun 10, 2020

Mechanistic insights into volatile anesthetic modulation of K2P channels

A. Wague, T. T. Joseph, K. A. Woll…·P. M. Riegelhaupt

This study identifies a volatile anesthetic binding site in TREK1 K2P channels and shows its role in modulating channel activity through molecular dynamics and mutagenesis.

DOI 10.7554/elife.59839

mechanistic / dynamical modelchromatin & epigenetic regulation

𝕏 PostBluesky

BiophysicsbioRxivAug 7, 2019

Direct Binding of Phosphatidylglycerol at Specific Sites Modulates Desensitization of a Pentameric Ligand-Gated Ion Channel

A. Tong, J. T. Petroff, F.-F. Hsu…·W. W. Cheng

The paper shows that phosphatidylglycerol binds to and stabilizes the pentameric ligand-gated ion channel ELIC, reducing desensitization.

DOI 10.7554/elife.50766

experimental assaycell signaling & trafficking

𝕏 PostBluesky

BiochemistrybioRxivNov 5, 2018

Cryo-EM structures reveal bilayer remodeling during Ca2+ activation of a TMEM16 scramblase

M. E. Falzone, J. Rheinberger, B.-C. Lee…·A. Accardi

The paper presents cryo-EM structures of a fungal TMEM16 scramblase showing Ca2+-induced conformational changes and membrane reorganization.

DOI 10.7554/elife.43229

fungi (other)cryo-EM

𝕏 PostBluesky