Chronic BCR signaling generates and maintains age-associated B cells from anergic B cells
K. Imabayashi, Y. Yada, M. Ushijima, M. Yoshimura, T. Iwasaki, K. Akashi, H. Niiro, Y. Baba
This study shows chronic BCR signaling generates and maintains age-associated B cells from anergic B cells, and Btk inhibition reduces ABCs and lupus pathogenicity.
bioRxiv · Jul 26, 2023 · PreprintImmunology