Y. Mori

Anesthetic-Binding Induced Motion of GABA A Receptors Revealed by Coarse-Grained Molecular Dynamics Simulations

This study uses coarse-grained molecular dynamics simulations to analyze how anesthetic binding affects the motion of GABAA receptors, revealing characteristic pore motion related to gate-opening.

Quantitative analysis of calcium oxalate monohydrate and dihydrate for elucidating the formation mechanism of calcium oxalate kidney stones

This paper quantitatively analyzes calcium oxalate monohydrate and dihydrate in kidney stones using FTIR, PXRD, and micro-CT to understand their formation mechanisms.

Novel monoclonal antibodies showing broad neutralizing activity for SARS-CoV-2 variants including Omicrons BA.5 and BA.2.75

Discrimination of SARS-CoV-2 Omicron sub-lineages BA.1 and BA.2 using a high-resolution melting-based assay: A pilot study

This study develops a high-resolution melting assay to distinguish SARS-CoV-2 Omicron sub-lineages BA.1 and BA.2 using mutation patterns in the spike protein with 100% sensitivity and >97.5% specificity.

Evolutionary relations between mycorrhizal symbiosis and plant-plant communication in trees

The paper investigates the link between mycorrhizal symbiosis types and plant-plant communication in trees, finding that ECM promotes communication among conspecifics.

Inactivation of SARS-CoV-2 and influenza A virus by spraying hypochlorous acid solution and hydrogen peroxide solution in the form of Dry Fog

This study evaluates the effectiveness of dry fog disinfectants in inactivating SARS-CoV-2 and influenza A virus on surfaces.

All-trans retinoic acid induces GADD34 gene expression via transcriptional regulation by Six1-TLE3 and post-transcriptional regulation by p38-TTP in skeletal muscle

This study shows ATRA increases GADD34 expression in muscle through transcriptional activation and post-transcriptional stabilization, altering myosin heavy chain types in myotubes.

C-type natriuretic peptide facilitates autonomic Ca2+ entry in growth plate chondrocytes for stimulating bone growth

This study identifies a signaling pathway involving CNP, NPR2, PKG, BK channels, and TRPM7 that facilitates Ca2+ entry in growth plate chondrocytes to stimulate bone growth.

TRPM2 deficiency protects against atherosclerosis by inhibiting TRPM2-CD36 inflammatory axis in macrophages

This study shows TRPM2 deficiency protects against atherosclerosis by inhibiting the TRPM2-CD36 inflammatory axis in macrophages, reducing plaque burden and inflammation.

The mechanosensitive Ca2+-permeable ion channel PIEZO1 promotes satellite cell function in skeletal muscle regeneration

This study shows that PIEZO1, a mechanosensitive ion channel, promotes satellite cell function and skeletal muscle regeneration by mediating calcium influx and RhoA-mediated actomyosin formation.

Strong intracellular signal inactivation produces sharper and more robust signaling from cell membrane to nucleus

The paper models how signal inactivation sharpens and stabilizes chemical signal propagation through the cytosol by filtering non-geodesic paths in human B cells.

The roseoloviruses downregulate the protein tyrosine phosphatase PTPRC(CD45)

This study identifies that HHV6A and HHV7 downregulate CD45 on T cells, impairing immune signaling and potentially promoting viral latency.

GP96 drives exacerbation of secondary bacterial pneumonia following influenza A virus infection

This study shows that GP96 promotes pneumococcal adherence to IAV-infected epithelial cells, leading to bacterial pneumonia, and that inhibiting GP96 reduces lung infection and pathology.

Orphan nuclear receptor COUP-TFII drives the myofibroblast metabolic shift leading to fibrosis

This study identifies COUP-TFII as a driver of myofibroblast metabolic shift to aerobic glycolysis, promoting fibrosis in multiple organs.

Three-dimensional understanding of the morphological complexity of the human uterine endometrium

This study uses 3D imaging to reveal the complex morphology of human endometrial glands and their pathological features in adenomyosis.

A Germinal Center-Associated Microenvironmental Signature Reflects Malignant Phenotype and Outcome of Diffuse Large B-cell Lymphoma

The paper identifies a germinal center-associated microenvironmental signature in DLBCL that correlates with prognosis and molecular features, showing its impact on clinical outcomes.

Native RNA sequencing on nanopore arrays redefines the transcriptional complexity of a viral pathogen

This study uses nRNA-seq to analyze the herpes simplex virus type 1 transcriptome, identifying a novel intergenic mRNA encoding a fusion protein of ICP0 and L.

The effect of anti-IL-6 receptor antibody for the treatment of McH-lpr/lpr-RA1 mice that spontaneously developed ankylosing arthritis

This study evaluates the effectiveness of an anti-IL-6 receptor antibody in reducing synovitis and bone destruction in McH-lpr/lpr-RA1 mice with ankylosing arthritis, showing partial success in inflammation but not in preventing ankylosis progression.