Multiplexed Single-Molecule Epigenetic Analysis of Plasma-Isolated Nucleosomes for Cancer Diagnostics
V. Fedyuk, N. Erez, N. Furth, O. Beresh, D. Jones, A. Shinde, K. Andreishcheva, B. B. Zakai, Y. Mavor, T. Peretz, A. Hubert, J. E. Cohen, A. Salah, M. Temper, A. Grinshpun, , E. Shema
The paper develops EPINUC, a single-molecule assay for analyzing plasma nucleosomes to detect cancer with high accuracy, including early-stage colorectal cancer and determining tumor origin.
bioRxiv · Nov 1, 2021Cancer Biology