Subtyping of Small Cell Lung Cancer using plasma cell-free nucleosomes
G. Fialkoff, N. Takahashi, I. Sharkia, J. Gutin, N. Hermoni, R. Kumar, L. Pongor, S. Nichols, L. Sciuto, C. Graham, P. Desai, M. Nirula, P. Suresh, M. Abel, R. Elmeskini, , A. Thomas
This study uses cfChIP-seq on plasma samples to subtype SCLC based on epigenetic states, linking plasma nucleosome data to tumor transcriptomes and developing a classifier for lineage-defining transcription factors.
bioRxiv · Jun 24, 2022 · PreprintCancer Biology