Author

E. Shema

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell-cell communication· 2 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

N. Furth· 5 shared G. Ron· 3 shared O. Beresh· 3 shared V. Fedyuk· 3 shared A. Harmelin· 2 shared B. Dassa· 2 shared D. Algranati· 2 shared D. Jones· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersCancer Biology

N. Furth

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5 papers

Recent·Most cited

Dual Targeting of Histone Deacetylases and MYC as Potential Treatment Strategy for H3-K27M Pediatric Gliomas

D. Algranati, R. Oren, B. Dassa, L. Fellus-Alyagor, A. Plotnikov, H. Barr, A. Harmelin, N. London, G. Ron, N. Furth, E. Shema

This study investigates dual targeting of HDACs and MYC in H3-K27M pediatric gliomas, showing synergistic effects in reducing cell viability and tumor growth.

bioRxiv · Feb 5, 2024Cancer Biology

Single-molecule systems for detection and monitoring of plasma circulating nucleosomes and oncoproteins in Diffuse Midline Glioma

N. Erez, N. Furth, V. Fedyuk, J. Wadden, R. Aittaleb, K. Schwark, M. Niculcea, M. Miclea, R. Mody, A. Franson, A. Eze, N. Nourmohammadi, J. Nazarian, S. Venneti, C. Koschmann, E. Shema

This paper develops a single-molecule system to detect and monitor plasma nucleosomes and oncoproteins in Diffuse Midline Glioma patients, showing clinical utility for non-invasive diagnostics.

bioRxiv · Nov 21, 2023Cancer Biology

Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas

N. Harpaz, T. Mittelman, O. Beresh, O. Griess, N. Furth, T. M. Salame, R. Oren, L. Fellus-Alyagor, A. Harmelin, S. Alexandrescu, J. G. Marques, M. G. Filbin, G. Ron, E. Shema

The paper uses CyTOF to analyze histone modifications in DIPG tumors, identifying two epigenetically distinct subpopulations with differential proliferation and marker expression.

bioRxiv · Nov 2, 2021Cancer Biology

Multiplexed Single-Molecule Epigenetic Analysis of Plasma-Isolated Nucleosomes for Cancer Diagnostics

V. Fedyuk, N. Erez, N. Furth, O. Beresh, D. Jones, A. Shinde, K. Andreishcheva, B. B. Zakai, Y. Mavor, T. Peretz, A. Hubert, J. E. Cohen, A. Salah, M. Temper, A. Grinshpun, , E. Shema

The paper develops EPINUC, a single-molecule assay for analyzing plasma nucleosomes to detect cancer with high accuracy, including early-stage colorectal cancer and determining tumor origin.

bioRxiv · Nov 1, 2021Cancer Biology

H3-K27M-Mutant Nucleosomes Interact with MLL1 to Shape the Glioma Epigenetic Landscape

N. Furth, D. Algranati, B. Dassa, O. Beresh, V. Fedyuk, N. Morris, L. Kasper, D. Jones, M. Monje, S. Baker, E. Shema

This study shows H3-K27M mutations alter chromatin marks by affecting PRC2 and MLL1 interactions, leading to bivalent chromatin and supporting glioma development.

bioRxiv · Aug 9, 2021Cancer Biology