Shear flow-driven actin re-organization induces ICAM-1 nanoclustering on endothelial cells that impact T-cell migration
I. Piechocka, S. Keary, A. Sosa-Costa, L. Lau, N. Mohan, J. Stanisavljevic, K. Borgman, M. Lakadamyali, C. Manzo, M. F. Garcia-Parajo
This study shows that shear forces induce ICAM-1 nanoclustering on endothelial cells through actin re-organization, enhancing T-cell migration by strengthening adhesion and reducing actin retrograde flow.
bioRxiv · Jun 29, 2020 · PreprintCell Biology