L. Lau

Downregulation of PIK3IP1/TrIP on T cells is controlled by TCR signal strength, PKC, and metalloprotease-mediated cleavage

This study identifies mechanisms controlling TrIP downregulation on T cells, showing it depends on TCR signal strength, PKC, and ADAM proteases.

Temporal dynamics and genomic programming of plasma cell fates

This study identifies a novel PC transition state and shows that long-lived plasma cells arise from late-phase GC responses through TIGIT-dependent clonal expansion.

Lipocalin 2 upregulation mediates the detrimental effects of therapy-induced senescence in breast cancer cells.

This study shows that Lipocalin 2 upregulation in breast cancer cells driven by therapy-induced senescence promotes migration and reduces chemotherapy effectiveness, correlating with poor patient survival.

Physiological activation of the nephron central command drives endogenous kidney tissue regeneration

This study identifies a novel kidney regeneration mechanism triggered by physiological stress, involving macula densa cells controlling progenitor cells through secreted factors.

Shear flow-driven actin re-organization induces ICAM-1 nanoclustering on endothelial cells that impact T-cell migration

This study shows that shear forces induce ICAM-1 nanoclustering on endothelial cells through actin re-organization, enhancing T-cell migration by strengthening adhesion and reducing actin retrograde flow.