C. Manzo

Learning Continuous 2D Diffusion Maps from Particle Trajectories without Data Binning

The paper develops a Bayesian method using Gaussian Processes to map diffusion coefficients continuously across membranes from particle trajectories without data binning.

ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin

This study shows ICAM-1 nanoclusters control hepatic epithelial cell polarity through actomyosin regulation, independent of leukocyte adhesion.

Actin-regulated Siglec-1 nanoclustering influences HIV-1 capture and virus-containing compartment formation in dendritic cells

This study shows that actin-regulated Siglec-1 nanoclustering in activated dendritic cells enhances HIV-1 capture and trafficking into a single viral-containing compartment.

Shear flow-driven actin re-organization induces ICAM-1 nanoclustering on endothelial cells that impact T-cell migration

This study shows that shear forces induce ICAM-1 nanoclustering on endothelial cells through actin re-organization, enhancing T-cell migration by strengthening adhesion and reducing actin retrograde flow.

Membrane receptor MerTK is a newly identified transcriptional regulator that associates to chromatin as nanoclusters during human DC differentiation

This study identifies MerTK as a transcriptional regulator in human dendritic cells, showing its nuclear translocation and clustering during differentiation.

Dynamic actin-mediated nano-scale clustering of CD44 regulates its meso-scale organization at the plasma membrane

This study reveals that CD44 forms a meso-scale meshwork at the plasma membrane, regulated by actin dynamics and nano-scale clustering.

Quantifying motor protein copy number in super-resolution using an imaging invariant calibration

This study quantifies motor protein copy number in super-resolution images using a DNA origami-based calibration method, showing dynein exists as single motors in cytosol and multimers on microtubules.