K. C. Mok

This study evolves E. coli with a less-effective cobamide to identify genetic adaptations that improve growth, finding increased BtuB expression and BtuR overexpression enhance cobamide-dependent growth.

The paper investigates corrinoid production and dependence in soil bacteria to understand metabolic interactions, finding metabolic compatibility and conserved traits across genera.

The paper investigates cobalamin riboswitches in Bacillus subtilis and finds they respond to multiple corrinoid cofactors, using structural conformation differences for regulation.

This paper identifies a novel cobamide remodeling enzyme, CbiR, in Akkermansia muciniphila that enables the bacterium to use diverse cobamides by modifying their structure.

This study investigates how structural variations in cobamides affect the binding selectivity of methylmalonyl-CoA mutase, showing that in vitro binding correlates with in vivo cobamide dependence.

The paper uses comparative genomics to analyze cobamide biosynthesis and dependence in bacteria, finding that most bacteria use cobamides but few synthesize them de novo.