Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells
T. Rothenburger, D. Thomas, Y. Schreiber, P. R. Wratil, T. Pflantz, K. Knecht, K. Digianantonio, J. Temple, C. Schneider, H.-M. Baldauf, K.-M. McLaughlin, F. Rothweiler, B. Bilen, S. Farmand, D. Bojkova, , J. Cinatl
This study identifies intrinsic and acquired resistance mechanisms to CNDAC and related nucleoside analogues in AML cells, showing distinct roles of SAMHD1 and DCK.
bioRxiv · Jul 19, 2021Pharmacology & Toxicology