D. Thomas

A molecularly engineered lectin destroys EGFR and inhibits the growth of non-small cell lung cancer

This paper demonstrates that the engineered lectin H84T binds to and inhibits NSCLC cell growth by lysosomal degradation of EGFR, independent of EGFR mutation status.

Tumor- and Nerve-Derived Axon Guidance Molecule Promotes Pancreatic Ductal Adenocarcinoma Progression and Metastasis through Macrophage Reprogramming

This study identifies SEMA3D as a dual driver of pancreatic ductal adenocarcinoma progression and metastasis through tumor- and nerve-derived mechanisms involving macrophage reprogramming.

Mitochondrial translocation of TFEB regulates complex I and inflammation

This study shows TFEB regulates mitochondrial complex I and inflammation through non-transcriptional mechanisms, with implications for immune pathogenesis during infection.

Macromolecular crowding is surprisingly unable to deform the structure of a model biomolecular condensate

This study investigates how macromolecular crowding affects model biomolecular condensates, finding that crowding agents do not significantly alter their structure.

THE RELATIONSHIP BETWEEN TERROIR AND THE PHENOLOGY OF BAROSSA SHIRAZ

This study examines how terroir factors influence vine phenology across the Barossa Valley, showing temperature and canopy size drive development before and after flowering, respectively.

Genetically modified IL-2 bone marrow-derived myeloid cells reprogram the glioma immunosuppressive tumormicroenvironment

This study shows that genetically modified myeloid cells releasing IL-2 can reprogram the glioma tumor microenvironment to enhance anti-tumor immunity in a mouse model.

Small molecule mediated stabilization of PP2A modulates the Homologous Recombination pathway and potentiates DNA damage-induced cell death

This study shows that stabilizing PP2A with a small molecule enhances DNA damage-induced apoptosis in HGSC cells and xenografts, both alone and with PARPi, by inhibiting HR and targeting RAD51.

Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR

This paper identifies a macrocycle that stabilizes the 14-3-3/CFTR complex, enhancing CFTR membrane localization and activity, particularly for the F508del mutation.

Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells

This study identifies intrinsic and acquired resistance mechanisms to CNDAC and related nucleoside analogues in AML cells, showing distinct roles of SAMHD1 and DCK.

Identification of Leucinostatins from Ophiocordyceps sp. as Antiparasitic Agents Against Trypanosoma cruzi

This study identifies leucinostatins from fungi as potent antiparasitic agents against Trypanosoma cruzi, with one showing in vivo efficacy in a mouse model.

Mild CF Lung Disease is Associated with Bacterial Community Stability

The paper identifies five bacterial community types in CF patients and finds that community instability is linked to worse lung function outcomes.

Global Genetic Cartography of Urban Metagenomes andAnti-Microbial Resistance

The paper creates a global metagenomic atlas of urban microbial ecosystems, identifying novel species and geographic variation in antimicrobial resistance genes.

The Virucidal Efficacy of Oral Rinse Components Against SARS-CoV-2 In Vitro

This study tests the virucidal efficacy of oral rinses against SARS-CoV-2 in vitro, finding that some formulations achieve significant virus inactivation.

Cardiac glycosides cause selective cytotoxicity in human macrophages and ameliorate white adipose tissue homeostasis

This study shows cardiac glycosides induce cytotoxicity in human macrophages and improve white adipose tissue homeostasis in obese patients.

Quantifying fluorescent glycan uptake to elucidate strain-level variability in foraging behaviors of rumen bacteria

The paper uses fluorescent glycan uptake and genomic analyses to study strain-level differences in carbohydrate metabolism among rumen bacteria.

Temporal Changes Guided by Mesenchymal Stem Cells on a 3D Microgel Platform Enhances Angiogenesis In Vivo at a Low-Cell Dose

This study shows that preconditioning mesenchymal stem cells on a 3D microgel platform enhances angiogenesis in vivo at a low-cell dose by modulating extracellular stiffness and integrin signaling.

Metabolite profiling of experimental cutaneous leishmaniasis lesions demonstrates significant perturbations in tissue phospholipids

This study uses metabolomics to show significant changes in phospholipids in cutaneous leishmaniasis lesions and adjacent healthy tissue in mice.

Reflux of Endoplasmic Reticulum proteins to the cytosol yields inactivation of tumor suppressors

The paper identifies a mechanism where ER proteins are refluxed to the cytosol, inactivating tumor suppressors like p53 in glioblastoma cells.

KMT2D Links TGF-β Signalling to Non-Canonical Activin Pathway and Regulates Pancreatic Cancer Cell Plasticity

This study identifies KMT2D as a tumor suppressor in pancreatic cancer, linking TGF-β signaling to the non-canonical activin A pathway through miR-147b and showing its role in cancer cell plasticity and metastasis.

Deficient ER acetyl-CoA import in acinar cells leads to chronic pancreatitis

This study shows that deficiency in ER acetyl-CoA import via AT-1 in acinar cells leads to chronic pancreatitis through ER stress and fibrosis.

Drivers of grass endophyte communities in prairies of the Pacific Northwest, USA

The paper investigates grass endophyte communities in prairies, finding climate as the strongest predictor of fungal community structure and noting dispersal limitations and seasonal variation.

3D mapping of host-parasite-microbiome interactions reveals metabolic determinants of tissue tropism and disease tolerance in Chagas disease

This study maps host-parasite-microbiome interactions in Chagas disease, identifying metabolic factors that influence tissue tropism and disease tolerance.

Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index

This study identifies mebendazole as a potential differentiation therapy for AML using a novel computational method called LMI, showing it induces differentiation and improves survival in mouse models.

The menstrual cycle is a primary contributor to cyclic variation in women’s mood, behavior, and vital signs

The paper identifies the menstrual cycle as the primary driver of cyclic variation in women's mood, behavior, and vital signs across 109 countries.

Large-scale genome-wide association meta-analysis of endometriosis reveals 13 novel loci and genetically-associated comorbidity with other pain conditions

This study identifies 13 novel genetic loci associated with endometriosis through a large GWAS meta-analysis and finds genetic links to other pain-related conditions.

The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1

This study investigates how cancer drugs interact with SAMHD1's catalytic and allosteric sites, finding that drug efficacy is affected by SAMHD1 activity and that only cladribine-TP induces the active tetramer.

Non-invasive measurement of hepatic venous oxygen saturation (ShvO2) with quantitative susceptibility mapping in normal mouse liver and livers bearing colorectal metastases

This study uses quantitative susceptibility mapping (QSM) to non-invasively measure hepatic venous oxygen saturation in mice, showing significant differences in oxygen levels between healthy livers and those with colorectal metastases.

Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection

This study fine-maps genetic loci associated with spontaneous clearance of hepatitis C virus infection, identifying a narrower region in the MHC locus and suggesting subtype-specific effects.