K.-M. McLaughlin

Resistance patterns in drug-adapted cancer cell lines reflect complex evolution in clinical tumors

This study identifies drug-resistant sublines of TNBC cell lines and finds that resistance mechanisms are unique and unpredictable, suggesting new potential drug targets.

Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells

This study identifies intrinsic and acquired resistance mechanisms to CNDAC and related nucleoside analogues in AML cells, showing distinct roles of SAMHD1 and DCK.

Multifaceted roles of SAMHD1 in cancer

This study analyzes SAMHD1's role in cancer using TCGA and TARGET databases, finding no consistent tumour suppressor effect and suggesting context-dependent pro-or anti-tumourigenic effects.

CD47 as a potential biomarker for the early diagnosis of severe COVID-19

This study identifies CD47 as a potential biomarker for early diagnosis of severe COVID-19 by showing its increased levels in SARS-CoV-2 infection and association with risk factors and complications.

COVID-19-related coagulopathy, is transferrin a missing link?

The paper identifies transferrin as a potential coagulation promoter in COVID-19, showing age-related increases, sex differences, and upregulation upon infection.

SARS-CoV-2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles

This study compares SARS-CoV-2 and SARS-CoV in cell tropism and drug sensitivity, finding differences in conservation, receptor usage, and therapeutic responses to aprotinin and remdesivir.

SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine

This study identifies SAMHD1 as a key regulator of nelarabine response in acute lymphoblastic leukaemias, showing lineage-specific differences in SAMHD1 expression and methylation.