Cancer BiologybioRxiv
Werner syndrome helicase is a selective vulnerability of microsatellite instability high tumor cells
S. Lieb, S. Blaha-Ostermann, E. Kamper…·S. Woehrle
This study identifies Werner syndrome helicase (WRN) as a selective vulnerability in microsatellite instability-high (MSI-H) cancer cells, showing that its inactivation impairs viability and causes genomic instability.
DOI 10.7554/elife.43333