Author

S. Lieb

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

M. Petronczki· 3 shared N. Kraut· 3 shared A. Schlattl· 2 shared M. Pearson· 2 shared A. A. Machado· 1 shared A. E. Gavard· 1 shared A. Jeschko· 1 shared A. Sorokin· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCancer Biology

M. Petronczki

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Author profile →

4 papers

Recent·Most cited

Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance

V. Thatikonda, H. Lu, S. Jurado, K. Kostyrko, C. A. Bristow, K. Bosch, N. Feng, S. Gao, D. Gerlach, M. Gerlach, S. Lieb, A. Jeschko, A. A. Machado, E. D. Marszalek, M. Mahendra, , M. H. Hofmann

This study shows that combining KRASG12C and SOS1 inhibitors improves anti-tumor response and delays resistance in KRASG12C-driven cancers.

bioRxiv · Jan 23, 2023Cancer Biology

Crystal Structure of the Werner's Syndrome Helicase

J. A. Newman, A. E. Gavard, S. Lieb, M. C. Ravichandran, K. Hauer, P. Werni, L. Geist, J. Boettcher, J. R. Engen, K. Rumpel, M. Samwer, M. Petronczki, O. Gileadi

This study determines the crystal structure of the WRN helicase core and identifies structural features that may aid in designing inhibitors against WRN helicase.

bioRxiv · May 4, 2020 · PreprintBiochemistry

Werner syndrome helicase is a selective vulnerability of microsatellite instability high tumor cells

S. Lieb, S. Blaha-Ostermann, E. Kamper, K. Ehrenhoefer-Woelfer, A. Schlattl, A. Wernitznig, J. J. Lipp, K. Nagasaka, G. Bader, R. A. Neumueller, N. Kraut, M. A. Pearson, M. Petronczki, S. Woehrle

This study identifies Werner syndrome helicase (WRN) as a selective vulnerability in microsatellite instability-high (MSI-H) cancer cells, showing that its inactivation impairs viability and causes genomic instability.

bioRxiv · Jan 26, 2019Cancer Biology

Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts

P. van der Lelij, S. Lieb, J. Jude, G. Wutz, C. P. Santos, K. Falkenberg, A. Schlattl, J. Ban, R. Schwentner, T. Hoffmann, H. Kovar, F. X. Real, T. Waldman, M. Pearson, N. Kraut, , M. P. Petronczki

The paper identifies a synthetic lethal relationship between STAG1 and STAG2 in cancers, showing STAG1 inactivation selectively targets STAG2-mutated cancer cells.

bioRxiv · Jun 25, 2017Cancer Biology