K. Nagasaka

This paper develops injectable hydrogels with microcapillary networks to improve stem cell transplantation by enhancing tissue integration and graft survival.

This study shows cohesin uses distinct mechanisms for DNA loop extrusion and sister chromatid cohesion, and that CTCF boundary interactions may rely on related mechanisms.

The paper shows CTCF blocks cohesin-mediated DNA loop extrusion and regulates its direction and loop size, revealing it as an active regulator rather than a passive barrier.

This paper develops a hotmelt tissue adhesive that prevents postoperative abdominal adhesions by controlling sol-gel transitions through supramolecular hydrogen bonding.

The paper shows that ESCO1 and CTCF protect cohesinSTAG1 from WAPL, enabling long chromatin loops that persist during G1-phase.

The paper measures absolute copy numbers and dynamics of cohesin, CTCF, and related proteins in human cells, revealing that some genomic enrichment sites are unoccupied in single cells.

This study identifies Werner syndrome helicase (WRN) as a selective vulnerability in microsatellite instability-high (MSI-H) cancer cells, showing that its inactivation impairs viability and causes genomic instability.