The GDF15-GFRAL pathway is dispensable for the effects of metformin on energy balance
A. B. Klein, T. S. Nicolaisen, K. Johann, A. M. Fritzen, C. V. Mathiesen, C. Gil, N. S. Pilmark, K. Karstoft, M. B. Blond, J. S. Quist, R. J. Seeley, K. Faerch, J. Lund, M. Kleinert, C. Clemmensen
This study shows metformin increases GDF15 but does not rely on the GDF15-GFRAL pathway for its weight-lowering effects in mice.
bioRxiv · Feb 16, 2022Physiology