C. Gil

Unravelling the Role of Candida albicans Prn1 in the Oxidative Stress Response Through a Proteomic Approach

This paper uses proteomics to show that Prn1 in Candida albicans is critical for oxidative stress response, affecting protein abundance, survival, and apoptosis.

Lysosomal MLKL is balanced by ESCRT to control cell death

The paper shows lysosomal MLKL is activated independently of RIPK3 and necroptosis, leading to cell death, which is counteracted by ESCRT machinery through lysosomal repair and sequestration of MLKL.

Cross-species comparison of pregnancy-induced GDF15

This study compares GDF15 expression during pregnancy across species, finding significant differences in plasma levels and expression between humans/macacaques and rodents.

Identification of leukemia-associated immunophenotypes by database-guided flow cytometry provides a highly sensitive and reproduciblestrategy for the study of measurable residual disease in acutemyeloblastic leukemia

This study identifies leukemia-associated immunophenotypes using database-guided flow cytometry, enabling sensitive and reproducible monitoring of measurable residual disease in acute myeloid leukemia.

Statistical evaluation of metaproteomics and 16s rRNA amplicon sequencing techniques for the study of the gut microbiota establishment of infants with cystic fibrosis

This study compares 16S rRNA amplicon sequencing and metaproteomics for analyzing gut microbiota in infants with cystic fibrosis, finding similar taxonomic assignments but discrepancies in abundance detection.

The GDF15-GFRAL pathway is dispensable for the effects of metformin on energy balance

This study shows metformin increases GDF15 but does not rely on the GDF15-GFRAL pathway for its weight-lowering effects in mice.

SARS-CoV-2 Infects Syncytiotrophoblast and Activates Inflammatory Responses in the Placenta

This study investigates SARS-CoV-2 infection in placentas from infected pregnant women, finding that the virus infects syncytiotrophoblast cells and triggers maternal immune cell infiltration.

Extending the proteomic characterization of Candida albicans exposed to stress and apoptotic inducers through data-independent acquisition mass spectrometry

This paper uses DIA-MS to characterize proteomic changes in C. albicans under stress and apoptotic conditions, identifying key proteins involved in oxidative stress response and apoptosis.

Identification of NPC1 as a novel SARS-CoV-2 intracellular target

The paper identifies NPC1 as a novel SARS-CoV-2 intracellular target, showing its interaction with the viral nucleoprotein and its inhibition by small molecules that also block EBOV entry.

Host-directed FDA-approved drugs with antiviral activity against SARS-CoV-2 identified by hierarchical in silico/in vitro screening methods

The paper identifies five FDA-approved drugs with antiviral activity against SARS-CoV-2 using a combined in silico and in vitro screening approach.

A wide-ranging Pseudomonas aeruginosa PeptideAtlas build: a useful proteomic resource for a versatile pathogen.

The paper builds a comprehensive Pseudomonas aeruginosa PeptideAtlas with high proteome coverage, providing a valuable resource for proteomic studies of this pathogen.

Distinct human gut microbial taxonomic signatures uncovered with different sample processing and microbial cell disruption methods for metaproteomic analysis

This study evaluates different sample processing and microbial cell disruption methods for metaproteomic analysis of the human gut microbiota, identifying method-specific taxonomic and functional signatures.

Small extracellular vesicles secreted by Candida albicans hyphae have highly diverse protein cargoes that include virulence factors and stimulate macrophages

The paper analyzes extracellular vesicles from Candida albicans yeast and hyphal cells, finding hyphal EVs have more diverse protein cargoes, including virulence factors, and stimulate macrophages.

Rosiglitazone in the thawing medium improves mitochondrial function in stallion spermatozoa through Akt phosphorylation and reduction of caspase 3

This study shows rosiglitazone improves mitochondrial function in thawed stallion sperm by enhancing Akt phosphorylation and reducing caspase 3 activity.