M. Kleinert

Overfeeding does not increase energy expenditure or energy excretion in mice

This study shows overfeeding in mice does not increase energy expenditure or excretion, and weight gain is mainly countered by reduced food intake.

Pantothenate Kinase 4 controls efficient skeletal muscle energy substrate metabolism via acetyl-CoA

This study identifies PanK4 as a regulator of skeletal muscle energy metabolism, showing its role in acetyl-CoA regulation and metabolic flexibility.

Cross-species comparison of pregnancy-induced GDF15

This study compares GDF15 expression during pregnancy across species, finding significant differences in plasma levels and expression between humans/macacaques and rodents.

The GDF15-GFRAL pathway is dispensable for the effects of metformin on energy balance

This study shows metformin increases GDF15 but does not rely on the GDF15-GFRAL pathway for its weight-lowering effects in mice.

Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise

The paper shows that exercise increases circulating GDF15 levels, but this physiological increase does not suppress appetite or exercise motivation like pharmacological GDF15.