Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts
P. van der Lelij, S. Lieb, J. Jude, G. Wutz, C. P. Santos, K. Falkenberg, A. Schlattl, J. Ban, R. Schwentner, T. Hoffmann, H. Kovar, F. X. Real, T. Waldman, M. Pearson, N. Kraut, , M. P. Petronczki
The paper identifies a synthetic lethal relationship between STAG1 and STAG2 in cancers, showing STAG1 inactivation selectively targets STAG2-mutated cancer cells.
bioRxiv · Jun 25, 2017Cancer Biology