Author

H. Kovar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

F. Halbritter· 2 shared A. Bykov· 1 shared A. Schlattl· 1 shared A. Wenninger-Weinzierl· 1 shared B. Radic Sarikas· 1 shared B. Sax· 1 shared C. P. Santos· 1 shared C. Sturtzel· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

F. Halbritter

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Author profile →

3 papers

Recent·Most cited

YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1 mediated reprogramming of bone mesenchymal stem cells

H. Kovar, R. Noorizadeh, B. Sax, T. Javaheri, B. Radic Sarikas, V. Fock, M. Kauer, A. Bykov, V. Suresh, M. Schlederer, L. Kenner, G. Weber, W. Mikulits, F. Halbritter, R. Moriggl

The paper shows that IGF-1 reprograms bone mesenchymal stem cells in EWS::FLI1-mutant mice, leading to tumor formation, with Yap1 playing a central role, and suggests combined IGF-1R and YAP/TEAD inhibition as a potential treatment.

bioRxiv · Jul 15, 2024Cancer Biology

Automated compound testing in zebrafish xenografts identifies combined MCL-1 and BCL-XL inhibition to be effective against Ewing sarcoma

S. Grissenberger, C. Sturtzel, A. Wenninger-Weinzierl, E. Scheuringer, L. Bierbaumer, S. Pascoal, M. Toetzl, E. Tomazou, O. Delattre, D. Surdez, H. Kovar, F. Halbritter, M. Distel

bioRxiv · Jun 17, 2021 · PreprintCancer Biology

Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts

P. van der Lelij, S. Lieb, J. Jude, G. Wutz, C. P. Santos, K. Falkenberg, A. Schlattl, J. Ban, R. Schwentner, T. Hoffmann, H. Kovar, F. X. Real, T. Waldman, M. Pearson, N. Kraut, , M. P. Petronczki

The paper identifies a synthetic lethal relationship between STAG1 and STAG2 in cancers, showing STAG1 inactivation selectively targets STAG2-mutated cancer cells.

bioRxiv · Jun 25, 2017Cancer Biology