T. Hoffmann

Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites.

The paper screens the MMV Pathogen Box to identify compounds active against Toxoplasma gondii bradyzoites and finds the mitochondrial bc1-complex as a drug target.

The cytoplasmic phosphate level has a central regulatory role in the phosphate starvation response of Caulobacter crescentus

This study investigates how cytoplasmic phosphate levels regulate the phosphate starvation response in Caulobacter crescentus, revealing distinct physiological and transcriptional responses to environmental and cytoplasmic phosphate changes.

Evolution of a cis-acting SNP that controls Type VI Secretion in Vibrio cholerae

This study identifies a cis-acting SNP in Vibrio cholerae that controls Type VI Secretion System activity, switching between constitutive and inducible states based on environmental cues.

Transglutaminase mediated asprosin oligomerization allows its tissue storage as fibers

The paper identifies transglutaminase-mediated asprosin oligomerization and extracellular fiber formation in connective tissues, suggesting a new mechanism for tissue storage and regulation of asprosin bioavailability.

In vitro maturation of Toxoplasma gondii bradyzoites in human myotubes and their metabolomic characterization

This study develops an in vitro model of mature Toxoplasma gondii bradyzoite cysts in human myotubes and characterizes their metabolomic profile.

rec-Y2H matrix screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins

The paper uses rec-Y2H screening to identify direct protein-protein interactions among RNA-binding proteins, revealing new interactions and their implications for RNA processing and cancer.

Morphometry of SARS-CoV and SARS-CoV-2 particles in ultrathin plastic sections of infected Vero cell cultures.

The paper compares the morphology and size distribution of SARS-CoV and SARS-CoV-2 particles in Vero cell cultures using electron microscopy, finding similar particle sizes but a higher spike count in SARS-CoV.

Glycosylation of bioactive C13-apocarotenols in Nicotiana benthamiana and Mentha x piperita

The paper identifies six UGTs in Nicotiana benthamiana and Mentha x piperita that catalyze the glycosylation of C13-apocarotenols, modifying their bioactivity through glucosylation.

Precision identification and prediction of high mortality phenotypes and disease progression pathways in severe malaria without requiring longitudinal data

Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts

The paper identifies a synthetic lethal relationship between STAG1 and STAG2 in cancers, showing STAG1 inactivation selectively targets STAG2-mutated cancer cells.