Author

G. Wutz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

I. F. Davidson· 3 shared K. Nagasaka· 3 shared W. Tang· 3 shared J. M. Peters· 2 shared J.-M. Peters· 2 shared P. van der Lelij· 2 shared R. Stocsits· 2 shared A. Sanborn· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersCell Biology

I. F. Davidson

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Author profile →

4 papers

Recent·Most cited

Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms

K. Nagasaka, I. F. Davidson, R. Stocsits, W. Tang, G. Wutz, P. Batty, M. Panarotto, G. Litos, A. Schleiffer, D. W. Gerlich, J. M. Peters

This study shows cohesin uses distinct mechanisms for DNA loop extrusion and sister chromatid cohesion, and that CTCF boundary interactions may rely on related mechanisms.

bioRxiv · Sep 23, 2022Cell Biology

CTCF is a DNA-tension-dependent barrier to cohesin-mediated DNA loop extrusion

I. F. Davidson, R. Barth, M. Zaczek, J. van der Torre, W. Tang, K. Nagasaka, R. Janissen, J. Kerssemakers, G. Wutz, C. Dekker, J.-M. Peters

The paper shows CTCF blocks cohesin-mediated DNA loop extrusion and regulates its direction and loop size, revealing it as an active regulator rather than a passive barrier.

bioRxiv · Sep 8, 2022 · PreprintBiophysics

ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL

G. Wutz, B. T. G. St. Hilaire, R. Ladurner, R. Stocsits, K. Nagasaka, B. Pignard, A. Sanborn, W. Tang, C. Varnai, M. Ivanov, S. Schoenfelder, P. van der Lelij, X. Huang, G. Duernberger, E. Roitinger, , J. M. Peters

The paper shows that ESCO1 and CTCF protect cohesinSTAG1 from WAPL, enabling long chromatin loops that persist during G1-phase.

bioRxiv · Sep 23, 2019Cell Biology

Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts

P. van der Lelij, S. Lieb, J. Jude, G. Wutz, C. P. Santos, K. Falkenberg, A. Schlattl, J. Ban, R. Schwentner, T. Hoffmann, H. Kovar, F. X. Real, T. Waldman, M. Pearson, N. Kraut, , M. P. Petronczki

The paper identifies a synthetic lethal relationship between STAG1 and STAG2 in cancers, showing STAG1 inactivation selectively targets STAG2-mutated cancer cells.

bioRxiv · Jun 25, 2017Cancer Biology