Mycobacterium tuberculosis senses host Interferon- gamma via the membrane protein MmpL10
M. Ahmed, J. S. Mackenzie, R. Krause, B. Truebody, L. B. Tezera, D. Garay-Baquero, A. F. Vallejo, K. Govender, J. Adamson, P. Elkington, A. J. C. Steyn, A. Leslie
This study shows Mycobacterium tuberculosis senses IFN-γ via MmpL10, increasing respiration and virulence, and enhances INH efficacy against persistent bacteria.
bioRxiv · Nov 12, 2021Microbiology