Author

J. Giandhari

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

A. Sigal· 5 shared T. de Oliveira· 5 shared S. Cele· 4 shared G. Lustig· 3 shared L. Jackson· 3 shared F. Karim· 2 shared H. Tegally· 2 shared K. Khan· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersEvolutionary Biology

A. Sigal

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function

D. P. Martin, S. Lytras, A. G. Lucaci, W. Maier, B. Gruning, S. D. Shank, S. Weaver, O. S. MacLean, R. J. Orton, P. Lemey, M. F. Boni, H. Tegally, G. W. Harkins, C. Scheepers, J. N. Bhiman, , S. L. Kosakovsky Pond

The paper identifies 13 rare mutations in the Omicron S-gene that cluster in functionally important regions and likely impact Spike function, suggesting cooperative interactions that mitigate fitness costs.

bioRxiv · Jan 14, 2022 · PreprintEvolutionary Biology

SARS-CoV-2 cell-to-cell spread occurs rapidly and is insensitive to antibody neutralization

L. Jackson, H. Rodel, S.-H. Hwa, S. Cele, Y. Ganga, H. Tegally, M. Bernstein, J. Giandhari, COMMIT-KZN Team, B. I. Gosnell, K. Khan, W. Hanekom, F. Karim, T. de Oliveira, M.-Y. S. Moosa, A. Sigal

This study shows SARS-CoV-2 spreads rapidly between cells via fusion and is resistant to antibody neutralization, unlike cell-free virus.

bioRxiv · Jun 1, 2021 · PreprintMicrobiology

HIV cell-to-cell spread slows evolution of drug resistance

J. Hunter, S. Cele, L. Jackson, J. Giandhari, T. de Oliveira, G. Lustig, A. Sigal

This study shows that HIV cell-free infection accelerates the evolution of drug resistance compared to cell-to-cell spread, with cell-free infection enabling multidrug resistance in the presence of two reverse transcriptase inhibitors.

bioRxiv · Sep 4, 2020 · PreprintEvolutionary Biology

Complementation can maintain a quasispecies of drug sensitive and resistant HIV

L. Jackson, S. Cele, G. Lustig, J. Giandhari, T. de Oliveira, R. Neher, A. Sigal

The paper shows that complementation between drug-sensitive and resistant HIV genotypes maintains a stable quasispecies, preventing the resistant genotype from outcompeting the sensitive one.

bioRxiv · Apr 20, 2020 · PreprintEvolutionary Biology

The CNS in the face of ART contains T cell origin HIV which can lead to drug resistance

G. Lustig, S. Cele, F. Karim, Y. Ganga, K. Khan, B. Gosnell, Y. Moosa, R. Harrichandparsad, S. Marais, R. Gupta, A. Derache, J. Giandhari, T. de Oliveira, K. Govender, J. Adamson, , A. Sigal

The paper investigates the origin of HIV in the CNS of ART-suppressed individuals and finds T cell-derived HIV that can lead to drug resistance.

bioRxiv · Mar 25, 2019 · PreprintMicrobiology