F. Karim

Dysfunctional effector memory CD8 T cells in the bronchoalveolar compartment of people living with HIV

This study identifies dysfunctional effector memory CD8 T cells in the bronchoalveolar compartment of HIV-positive individuals, linked to reduced IL-17A production and increased regulatory molecule expression, contributing to susceptibility to tuberculosis.

Colon resident CD8+ T cells from people with HIV on antiretroviral therapy exhibit mitochondrial dysfunction and impaired responses

The paper examines CD8+ T cells in the colon of HIV patients on ART, finding impaired mitochondrial function and reduced immune responses compared to peripheral blood cells.

Discrepancy between Mtb-specific IFN-γ and IgG responses in HIV-positive people with low CD4 counts.

This study compares Mtb-specific IFN-γ and IgG responses in HIV-positive and HIV-negative individuals, finding higher IgG levels and lower QFT positivity in HIV-positive people with low CD4 counts.

Mapping the Spatial Dynamics of the Human Oral Mucosa in Chronic Inflammatory Disease

The paper maps spatial dynamics in human oral mucosa using single-cell and spatial transcriptomics to identify immune programs and pathogenic fibroblasts in chronic inflammation.

HIV skews the SARS-CoV-2 B cell response toward an extrafollicular maturation pathway

This study shows that HIV infection shifts the SARS-CoV-2 B cell response toward an extrafollicular pathway, leading to lower affinity antibodies and reduced vaccine efficacy in people living with HIV.

HIV-specific CD8+ T-cells in tonsils express exhaustive TRM-like signatures

The paper examines HIV-specific CD8+ T-cells in tonsils, finding they exhibit TRM-like exhaustion signatures compared to blood, with differences in natural HIV controllers.

A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

This study compares antibody responses to early SARS-CoV-2 isolates and the B.1.351 variant, finding shifts in immunodominance hierarchy within the spike receptor-binding domain.

SARS-CoV-2 cell-to-cell spread occurs rapidly and is insensitive to antibody neutralization

This study shows SARS-CoV-2 spreads rapidly between cells via fusion and is resistant to antibody neutralization, unlike cell-free virus.

Contrasting inflammatory signatures in peripheral blood and bronchoalveolar cells reveal compartment-specific effects of HIV infection.

This study compares HIV-induced gene expression in peripheral blood and bronchoalveolar cells, revealing distinct inflammatory signatures and compartment-specific effects.

Bund removal to re-establish tidal flow, remove aquatic weeds and restore coastal wetland services - North Queensland, Australia

This study investigates the impact of tidal reinstatement after bund removal on weed infestation, water quality, and fish biodiversity in a coastal wetland in North Queensland.

The CNS in the face of ART contains T cell origin HIV which can lead to drug resistance

The paper investigates the origin of HIV in the CNS of ART-suppressed individuals and finds T cell-derived HIV that can lead to drug resistance.