K. Haslinger

Identification and partial reconstitution of the biosynthetic pathway of bioactive meroterpenoids from Hericium erinaceus (Lion's Mane mushroom).

The paper identifies and partially reconstitutes the biosynthetic pathway of hericenones in Hericium erinaceus using heterologous expression in Aspergillus oryzae.

Discovery and heterologous expression of functional 4-O-dimethylallyl-L-tyrosine synthases from lichen-forming fungi.

The paper identifies and expresses two functional 4-O-dimethylallyl-L-tyrosine synthases from lichen-forming fungi, revealing their substrate specificity and potential for biocatalytic applications.

Genome sequencing and molecular networking analysis of the wild fungus Anthostomella pinea reveal its ability to produce a diverse range of secondary metabolites

This study sequenced the genome of Anthostomella pinea and analyzed its secondary metabolites, revealing 91 biosynthetic gene clusters and the antibiotic xanthoepocin.

Heterologous naringenin production in the filamentous fungus Penicillium rubens

This study produces naringenin in Penicillium rubens using genetic engineering and identifies a novel degradation pathway for this compound.

Structural characterization and extended substrate scope analysis of two Mg2+-dependent O-methyltransferases from bacteria

This study characterizes two bacterial O-methyltransferases, revealing their broad substrate scope and crystal structures, with implications for biocatalytic applications in drug development.

Engineering a plant polyketide synthase for the biosynthesis of methylated flavonoids

This study engineers a plant enzyme to increase the production of methylated flavonoids in engineered microbes.

Rapid in vitro prototyping of O-methyltransferases for pathway applications in Escherichia coli

This study develops a rapid in vitro workflow to screen O-methyltransferases for substrate and product ranges, enabling efficient biocatalyst prototyping.

Heterologous caffeic acid biosynthesis in Escherichia coli is affected by choice of tyrosine ammonia lyase and redox partners for bacterial Cytochrome P450

This paper improves caffeic acid production in E. coli by optimizing tyrosine ammonia lyase and redox partners for bacterial Cytochrome P450, achieving 47 mg/L from glucose.