B. Peng

A trustworthy semantic knowledge network linking data-driven cell phenotypes to diseases and drugs

The paper develops NLM-CKN, a semantic knowledge network linking cell phenotypes to diseases and drugs using integrated data from 88 datasets.

Enhancing radiotherapy response via intratumoral injection of the TLR9 agonist CpG to stimulate CD8 T cells in an autochthonous mouse model of sarcoma

This study shows that combining radiotherapy with CpG, a TLR9 agonist, enhances tumor response in a mouse sarcoma model by boosting CD8 T cell activity.

coRIC map: a framework for the exploration of multifaceted subcellular RNA-binding proteins

The paper introduces coRIC map, an experimental and analytical framework to study subcellular RNA-binding protein dynamics and interactions, revealing new functions and stress responses.

Heterologous naringenin production in the filamentous fungus Penicillium rubens

This study produces naringenin in Penicillium rubens using genetic engineering and identifies a novel degradation pathway for this compound.

ULK1-dependent phosphorylation of PKM2 antagonizes O-GlcNAcylation and inhibits the Warburg effect in breast cancer

This study identifies ULK1-mediated phosphorylation of PKM2 that inhibits O-GlcNAcylation and reduces the Warburg effect in breast cancer.

High dimensional analyses reveal activation of lymphocyte subsets and reversal of immunoresistance by cytokine enhancement of adoptive cellular vaccine therapy in prostate cancer.

This study shows IL-15 treatment enhances the anti-tumor efficacy of sipuleucel-T by increasing CD8+ T-cell and CD56+ NKT subset activity in prostate cancer.

Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level

This study identifies subtype-specific proteome and N-glycan alterations in medulloblastoma that may serve as therapeutic targets.

Engineering a plant polyketide synthase for the biosynthesis of methylated flavonoids

This study engineers a plant enzyme to increase the production of methylated flavonoids in engineered microbes.

PLK1 O-GlcNAcylation is essential for dividing mammalian cells and inhibits uterine carcinoma

This study identifies PLK1 O-GlcNAcylation as critical for cell division and shows its role in suppressing uterine carcinoma through biochemical and mouse model experiments.

Adult fibroblasts use aggresomes only in distinct cell-states

The paper examines aggresome formation in primary adult mouse fibroblasts across different cell-states, finding it occurs only in quiescent and immortalized cells, not in proliferating or senescent cells.

Molecular basis for SPINDOC-Spindlin1 engagement and its role in transcriptional inhibition

This paper identifies the molecular mechanism by which SPIN*DOC inhibits Spindlin1's transcriptional coactivator activity through multivalent binding and competitive inhibition.

Anacardic acid protects against phenylephrine-induced mouse cardiac hypertrophy through JNK signaling-dependent regulation of histone acetylation

This study shows anacardic acid reduces PE-induced cardiac hypertrophy by inhibiting JNK signaling and HAT-mediated histone acetylation in mice.

Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiate the DNA damage response and repair

This study shows that SIRT1 and SIRT6 work together to recognize DNA breaks and enhance the DNA damage response and repair.