T. He

NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis

This study identifies NSD2 as a critical component of the AR neo-enhanceosome in prostate cancer, showing its role in AR enhancer circuitry and tumor progression.

Horizontally acquired CSP genes contribute to wheat adaptation and improvement

This study identifies horizontally acquired CSP genes in wheat that enhance drought tolerance and photosynthetic efficiency, contributing to wheat adaptation and improvement.

PRR adjuvants restrain high stability peptides presentation on APCs

This study shows adjuvants like MPLA and CpG reduce high-stability peptide presentation on APCs, shifting T-cell immunodominant epitope responses.

PGC-1a drives small cell neuroendocrine cancer progression towards an ASCL1-expressing subtype with increased mitochondrial capacity

p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancer

This study shows that degrading p300/CBP in prostate cancer suppresses tumor growth more effectively than inhibiting their activity, highlighting their role in maintaining the active AR enhanceosome.

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer

This study identifies PIKfyve as a targetable vulnerability in pancreatic cancer by showing its role in lipid metabolism and synthetic lethality with KRAS-MAPK inhibitors.

Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer

This paper develops an orally bioavailable PROTAC degrader of mSWI/SNF ATPases for prostate cancer and identifies resistance mechanisms through long-term treatment.

PIKfyve controls dendritic cell function and tumor immunity

This study shows that PIKfyve inhibition enhances dendritic cell function and improves immunotherapy efficacy in tumor models.

A novel cell communication method reveals that grik4 and gabrd may be critical for inducing death in RGNNV-infected grouper.

The paper uses multi-omics methods to identify grik4 and gabrd as potential factors causing death in RGNNV-infected groupers through cell communication analysis.

Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies

This study identifies a therapeutic vulnerability in POU2F-POU2AF-driven cancers by showing that targeting the mSWI/SNF complex with a PROTAC degrader reduces tumor growth in preclinical models.

Genome sequencing and molecular networking analysis of the wild fungus Anthostomella pinea reveal its ability to produce a diverse range of secondary metabolites

This study sequenced the genome of Anthostomella pinea and analyzed its secondary metabolites, revealing 91 biosynthetic gene clusters and the antibiotic xanthoepocin.

Climate warming suppresses soil abundant fungal taxa and reduces soil carbon efflux in a semi-arid grassland

This study shows that warming reduces fungal abundance and shifts fungal community composition in semi-arid grasslands, leading to reduced soil carbon efflux.

P bodies coat germ granules to promote transgenerational gene silencing in C. elegans

This study shows P body factors coat germ granules in C. elegans to enable transgenerational gene silencing by maintaining small RNA factors and secondary small RNA amplification.

A di-arginine additive for dissociation of gold nanoparticle aggregates: A matrix-insensitive approach with applications in protease detection

This paper introduces a di-arginine additive for dissociating gold nanoparticle aggregates in complex matrices, enabling sensitive protease detection in biological fluids.

The diversity of the glycan shield of sarbecoviruses closely related to SARS-CoV-2

This study compares the glycan shields of sarbecoviruses to understand how sequence variations affect their structure and potential for antibody neutralization.

A miniaturized ultrasound transducer for monitoring full-mouth oral health: a preliminary study

This study develops a miniaturized ultrasound transducer for full-mouth oral health monitoring, demonstrating high-resolution imaging and accurate gingival thickness measurement.

Bile Acid Restrained T Cell Activation Explains Cholestasis Aggravated Hepatitis B Virus Infection

This study shows that bile acids impair CD4+ T cell activation in cholestasis, worsening HBV infection outcomes by disrupting calcium signaling and metabolic reprogramming.

GLH/VASA helicases promote germ granule formation to ensure the fidelity of piRNA-mediated transcriptome surveillance

This study shows that GLH/VASA helicases are essential for forming germ granules, which ensure accurate piRNA-mediated transcriptome surveillance by distinguishing self from non-self.

Broccoli sprout Sulforaphane affected hemodynamics and aorta myogenic spontaneous rhythmic contraction in sanitized water uptake mice

This study examines how broccoli sprout sulforaphane affects hemodynamics and aortic myogenic contractions in mice consuming saline water.

Quaternary climate change explains global patterns of tree beta-diversity

The paper examines how Quaternary climate change influences tree beta-diversity globally, finding temperature changes since the Last Glacial Maximum strongly affect turnover and nestedness components.

Evaluation of azithromycin or hydroxychloroquine plus azithromycin combination therapy on cardiac conduction and function in guinea pigs

This study evaluates the cardiac effects of azithromycin and hydroxychloroquine plus azithromycin in guinea pigs, finding QT interval prolongation and cardiac dysfunction with both treatments.

Longitudinal multi-omics along gingivitis development reveal a suboptimal-health gum state with periodontitis-like microbiome

The paper identifies a suboptimal-health gum state (SoH) during experimental gingivitis, characterized by microbiome and metabolite changes similar to periodontitis.

A Computer-aided Method for Identifying the Presence of Softwood Growth Ring Boundaries

This paper develops a computer-aided method to assess growth ring boundaries in softwood using image processing, achieving 98% accuracy by analyzing 100 micro-images.

Paleoclimate and current climate collectively shape the phylogenetic and functional diversity of trees worldwide

The paper maps global tree diversity patterns and shows that both current and ancient climates influence tree species richness, functional, and phylogenetic diversity.

Half of the world's tree biodiversity is unprotected and is increasingly threatened by human activities

The paper identifies priority areas for global tree conservation and finds that half are unprotected and face human threats.

Rotten-skin disease significantly changed giant spiny frog(Paa spinosa) gut microbiota

This study compares gut microbiota composition between healthy and rotten-skin diseased giant spiny frogs using 16S rRNA sequencing and identifies significant microbial abundance differences.

Semaphorin 3a reduces the side effects of radiation on BMSCs by reducing ROS

This study shows that Sema3a reduces radiation-induced ROS levels and mitigates adverse effects on BMSCs by improving osteogenic differentiation and reducing adipogenic differentiation and inflammation.

Empathic contagious pain and consolation in laboratory rodents: species and sex comparisons

This study compares empathic responses in male and female mice and rats, finding no species difference in empathic behaviors but notable sex differences in mice.

Melanoma plasticity is controlled by a TRIM28-JUNB mediated switch

This paper identifies TRIM28-JUNB as a regulatory switch controlling melanoma phenotype switching between invasive and proliferative states.