L. Dai

Multi-omics reveals AKR1B1-regulated galactose metabolic as a driver of gastrointestinal stromal tumor progression

This study identifies AKR1B1-regulated galactose metabolism as a driver of gastrointestinal stromal tumor progression through multi-omics analysis.

Zinc finger transcription factors BnaSTOP2s regulate sulfur metabolism and confer resistance to Sclerotinia sclerotiorum in Brassica napus

Ultrasensitive amplification-free quantification of a methyl CpG-rich cancer biomarker by single-molecule kinetic fingerprinting

This paper develops an amplification-free method to quantify DNA methylation at the BCAT1 promoter with high sensitivity and specificity, enabling improved early detection of methylated cancer DNA biomarkers.

Molecular basis of inhibition of the amino acid transporter B0AT1 (SLC6A19)

This paper identifies high-affinity inhibitors of B0AT1 and elucidates their mechanism of action through cryo-EM structures.

Degradation of indole-3-acetic acid by plant-associated microbes

This study identifies bacterial isolates capable of degrading indole-3-acetic acid (IAA) from Arabidopsis and rice roots, revealing their functional roles and association with IAA producers.

Integrative Omics Uncovers Low Tumorous Magnesium Content as A Driver Factor of Colorectal Cancer

This study identifies low tumorous magnesium content as a driver factor of colorectal cancer by showing its impact on gene mutations, EMT activation, and cell migration through DBN1 phosphorylation.

SARS-CoV-2 Omicron BA.2.86: less neutralization evasion compared to XBB sub-variants

This study compares the immune evasion of SARS-CoV-2 Omicron BA.2.86 to XBB sub-variants, finding BA.2.86 shows less neutralization evasion.

Heterologous naringenin production in the filamentous fungus Penicillium rubens

This study produces naringenin in Penicillium rubens using genetic engineering and identifies a novel degradation pathway for this compound.

Neutralization of SARS-CoV-2 EG.5/EG.5.1 by sera from ZF2001 RBD-dimer and its next-generation vaccines

This study evaluates the neutralization of SARS-CoV-2 EG.5/EG.5.1 by sera from vaccinated individuals and breakthrough infections, finding that next-generation vaccines offer better protection against these variants.

Data-driven prediction of colonization outcomes for complex microbial communities

The paper predicts colonization outcomes of exogenous microbes in complex communities using a data-driven approach, validated with synthetic data and experimental tests.

Identifying keystone species in microbial communities using deep learning

This paper introduces a deep learning framework to identify keystone species in microbial communities using synthetic and real microbiome data, finding taxa with high keystoneness show community specificity.

Neutralization of SARS-CoV-2 BQ.1.1 and XBB.1.5 by Breakthrough Infection Sera from Previous and Current Waves in China

This study assesses neutralization of SARS-CoV-2 Omicron subvariants by sera from different vaccination and breakthrough infection cohorts, finding that BQ.1.1 and XBB.1.5 show strong neutralization evasion.

Label-free quantitative proteomics analyses of mouse astrocytes provides insight into the host response mechanism at different developmental stages of Toxoplasma gondii

This study uses label-free proteomics to analyze mouse astrocytes infected with different stages of Toxoplasma gondii, identifying differentially expressed proteins that reveal host response mechanisms in acute and chronic infections.

Different tissues in the maternal-fetal interface harbor distinct microbiomes showing associations related to their anatomical position or function

The study analyzes microbiome profiles across maternal-fetal tissues, revealing distinct microbial compositions and correlations based on anatomical position.

A High Fraction of Oral Bacteria in the Feces Indicates Gut Microbiota Depletion with Implications for Human Health

The paper investigates the association between oral bacteria in feces and gut microbiota depletion, supporting the Marker hypothesis over the Expansion hypothesis.

Bioinformatics analysis of immune-related prognostic genes and immunotherapy in renal clear cell carcinoma

The paper identifies 4 immunoprognostic genes in ccRCC using bioinformatics analysis of public databases and validates their association with prognosis and immunotherapy response.

Integrated analysis of intestinal microbiota and metabolomic reveals that decapod iridescent virus 1 (DIV1) infection induces secondary bacterial infection and metabolic reprogramming in Marsupenaeus japonicus

This study investigates how DIV1 infection in Marsupenaeus japonicus affects intestinal microbiota, metabolomics, and immune response, revealing secondary bacterial infection and metabolic reprogramming.

Ecological Dynamics Imposes Fundamental Challenges in Microbial Source Tracking

This study shows that existing microbial source tracking solvers fail to solve the MST problem when ecological dynamics, such as microbial interactions and priority effects, are present.

Septin-Mediated RhoA Activation Engages the Exocyst Complex to Recruit the Cilium Transition Zone

The paper shows SEPTIN9 activates RhoA to recruit the exocyst complex, facilitating ciliogenesis by enabling transition zone protein accumulation.

Reduced sera neutralization to Omicron SARS-CoV-2 by bothinactivated and protein subunit vaccines and the convalescents

The paper tests neutralization activity of sera from convalescents and vaccine recipients against Omicron, finding that vaccines maintain better neutralization than convalescents.

Observation of reversal in twist-stretch coupling of RNA suggests a unified mechanism for the opposite couplings of DNA and RNA

This study observes that RNA's twist-stretch coupling reverses from positive to negative with multivalent cations, proposing a unified mechanism for DNA and RNA coupling based on deformation pathways.

Ecological dynamics of the gut microbiome in response to dietary fiber

This study examines how dietary fiber affects gut microbiome dynamics and SCFAs in mice, showing baseline-dependent responses and the importance of ecological modeling.

Gastric cancer derived exosomes induce peritoneal mesothelial cell EMT through TGF-β1/Smads pathway to promote peritoneal metastasis

This study shows GC-derived exosomes induce EMT in peritoneal mesothelial cells via TGF-β1/Smads pathway, enhancing GC cell migration and adhesion.

Switching Promotor Recognition of Phage RNA Polymerase in Silico Following Path along Lab Directed Evolution

This study uses computational methods to investigate how phage RNA polymerase evolves to switch promoter recognition from T7 to T3 through structural and electrostatic changes.

Neutralization of recombinant RBD-subunit vaccine ZF2001-elicited antisera to SARS-CoV-2 variants including Delta

This study evaluates the neutralizing activity of ZF2001 vaccine-elicited antisera against SARS-CoV-2 variants, finding that E484K/Q mutations reduce neutralization and that extended intervals between doses improve variant resilience.

A drug candidate for treating adverse reactions caused by pathogenic antibodies inducible by COVID-19 virus and vaccines

This paper presents a drug candidate, NANA-Me, that prevents and treats ADAA-based diseases caused by pathogenic anti-spike antibodies in COVID-19 and vaccines.

Revealing Atomic-scale Molecular Diffusion of a Plant Transcription Factor WRKY domain protein along DNA

This study uses molecular dynamics simulations to reveal atomic-scale diffusion dynamics of the WRKY transcription factor along DNA, including base-pair stepping and strand preference.

Spatial profiling of microbial communities by sequential FISH with error-robust encoding

This paper introduces SEER-FISH, a method for spatially profiling microbial communities with high multiplexity and accuracy, demonstrating its ability to quantify taxon abundance and map microbial biogeography.

Establishment and Resilience of Transplanted Gut Microbiota in Aged Mice

This study investigates how age-matching between fecal microbiota transplantation (FMT) donors and aged recipients affects microbiota establishment and resilience, finding that mismatched age may reduce resilience against inflammation.

A tandem-repeat dimeric RBD protein-based COVID-19 vaccine ZF2001 protects mice and nonhuman primates

ZF2001, a tandem-repeat dimeric RBD protein vaccine, induces strong immune responses and protects mice and non-human primates from SARS-CoV-2 infection.