Cell BiologybioRxiv
Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling
B. Czaya, K. Heitman, I. Campos…·C. Faul
This study shows hyperphosphatemia causes inflammation, anemia, and muscle wasting in mice independently of FGF23-FGFR4 signaling, suggesting dietary phosphate restriction may benefit both CKD patients and healthy individuals.
DOI 10.7554/elife.74782