Phospholipase C β4 promotes RANKL-dependent osteoclastogenesis by interacting with MKK3 and p38 MAPK
D.-K. Lee, X. Jin, P.-R. Choi, Y. Cui, X. Che, S. Lee, K. Hur, H.-J. Kim, J.-Y. Choi
This study identifies PLCβ4 as a key regulator of RANKL-induced osteoclastogenesis by interacting with MKK3 and p38 MAPK, showing its potential as a therapeutic target for bone diseases.
bioRxiv · Mar 19, 2024Cell Biology