S.-H. Kim

Matrix-rigidity cooperates with biochemical cues in M2 macrophage activation through increased nuclear deformation and chromatin accessibility

This study shows matrix rigidity enhances M2 macrophage activation by altering nuclear mechanics and chromatin accessibility through cooperation with biochemical signals like IL4/13.

Development of novel high-resolution melting markers for the assessment of hybridization between Mauremys sinensis and Mauremys reevesii in South Korea

This study develops high-resolution melting markers to detect hybridization between Mauremys sinensis and Mauremys reevesii in South Korea, identifying hybrid individuals at multiple sites.

Subchronic exposure to ambient PM2.5 impairs novelty recognition and spatial memory

This study shows that subchronic exposure to high PM2.5 levels impairs novelty recognition and spatial memory in mice.

AMLs harboring DNMT3A-destabilizing variants show increased intratumor DNA methylation heterogeneity at bivalent chromatin domains

This study shows that DNMT3A-destabilizing mutations in AML increase DNA methylation heterogeneity at bivalent chromatin domains, affecting leukemic stem cell-niche interactions and drug response.

Cropbox: a declarative crop modeling framework

Cropbox provides a declarative framework for crop modeling, enabling transparent and accessible model development through automated code generation from high-level specifications.

Deconvoluting signals downstream of growth and immune receptor kinases by phosphocodes of the BSU1 family phosphatases

This study shows that BSU1 phosphatase uses different phosphorylation sites to transduce signals from brassinosteroid and flagellin receptors in plants.

On whole-genome demography of world ethnic groups and individual genomic identity

This paper proposes a whole-genome-based categorization system for ethnic groups and demonstrates that most of the genome is identical across individuals regardless of their ethnic group.

COP1 promotes seed germination by destabilizing RGA-LIKE2 (RGL2) in Arabidopsis

The paper identifies COP1 as an upstream negative regulator of RGL2, showing COP1 promotes seed germination by ubiquitinating and destabilizing RGL2 in Arabidopsis.

An integrative process-based model for biomass and yield estimation of hardneck garlic (Allium sativum)

The paper introduces an integrative process-based crop model for garlic to estimate biomass and yield under diverse environmental conditions and assess climate adaptation strategies.

A novel vascular endothelial growth factor-trap KP-VR2 with enhanced ligand blocking

This study develops KP-VR2, a novel VEGF-Trap that neutralizes VEGF-A, VEGF-B, and PlGF, showing improved antitumor efficacy compared to existing therapies.

Anterior insula-associated social novelty recognition: orchestrated regulation by a local retinoic acid cascade and oxytocin signaling

This study investigates the role of the anterior insula in social novelty recognition, showing its regulation by a local retinoic acid cascade and oxytocin signaling through a non-classical pathway.

The Flowering Time Regulator FLK Controls Pathogen Defense in Arabidopsis thaliana

This study identifies FLK as a regulator of pathogen defense in Arabidopsis, showing it affects resistance to bacterial and fungal pathogens through modulation of defense signaling and ROS scavenging.

Spatiotemporal Dynamics of Intra-tumoral Dependence on NEK2-EZH2 Signaling in Glioblastoma Cancer Progression

This study identifies NEK2-EZH2 signaling as critical for glioblastoma tumor core progression and resistance, and presents a novel inhibitor CMP3a that shows therapeutic potential.

Whole-proteome Tree of Insects: Grouping and phylogeny without sequence alignment

This paper constructs a whole-proteome tree of insects without sequence alignment, finding an explosive emergence of major groups near the root and a basal Hemiptera subgroup.

Novel mechanistic targets of Forkhead box Q1 transcription factor in human breast cancer cells

This study identifies novel mechanistic targets of FoxQ1 in human breast cancer cells using RNA-seq and chromatin immunoprecipitation, revealing its role in regulating IL-1, IL-8, and VEGF.

Inhibitory effects of β-caryophyllene on Helicobacter pylori infection in vitro and in vivo

This study demonstrates that β-caryophyllene inhibits H. pylori growth and infection through downregulation of virulence factors and bacterial replication machinery, with therapeutic effects confirmed in vivo.

Same same but different: a web-based deep learning application for the histopathologic distinction of cortical malformations

The paper trains a CNN to distinguish between FCD IIb and TSC using histopathologic images and develops a web app for classification.

Genome Tree of Life: Deep Burst of Organism Diversity

The paper reconstructs a Genome Tree of Life using proteome data from over 4000 organisms, suggesting a 'Deep Burst' of early life diversification into prokarya and eukarya.

Developing a primary Paralichthys olivaceus gill epithelial cells as an in vitro model for propagation of VHSV show a corresponding increase in cell viability with increase in protein concentration in growth media

This study develops a primary gill epithelial cell model from olive flounder to propagate VHSV, showing increased cell viability with higher fetal bovine serum concentration.

Neutrophil-derived extracellular vesicles: proinflammatory trails and anti-inflammatory microvesicles

This study identifies two neutrophil-derived extracellular vesicle subtypes with distinct inflammatory properties: proinflammatory NDTRs and anti-inflammatory NDMVs.

Castration-resistant prostate cancer: Androgen receptor inactivation induces telomere DNA damage, and damage response inhibition leads to cell death

This study shows that combining an AR antagonist with an ATM inhibitor induces telomere DNA damage and DDR inhibition, leading to cell death in CRPC cells.

Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis

The paper introduces a new syngeneic mouse model of spontaneous breast cancer brain metastasis and evaluates histone deacetylase inhibitors as potential therapies.

Mechanistic model of temperature influence on flowering through whole-plant accumulation of FT

The paper modifies an existing model to incorporate temperature effects on FT expression and leaf growth, showing how temperature influences flowering timing and FT accumulation in Arabidopsis.