H.-J. Kim

Targeting phosphatase DUSP22 ameliorates skeletal muscle wasting via Akt independent JNK-FOXO3a repression

This study identifies DUSP22 as a novel target for preventing skeletal muscle wasting by repressing the JNK-FOXO3a pathway independently of Akt.

Phospholipase C β4 promotes RANKL-dependent osteoclastogenesis by interacting with MKK3 and p38 MAPK

This study identifies PLCβ4 as a key regulator of RANKL-induced osteoclastogenesis by interacting with MKK3 and p38 MAPK, showing its potential as a therapeutic target for bone diseases.

Three-dimensional Label-Free Measurements of Adipocyte Differentiation and Lipid Droplet Dynamics

This study uses low-coherence holotomography to track adipocyte differentiation and lipid droplet dynamics over 42 days without labeling.

Pan-cancer analysis reveals multifaceted roles of retrotransposon-fusion RNAs

The paper identifies cancer-specific transposon-fusion RNAs across 34 cancer types and finds they are associated with tumor suppressors and oncogenes, and can activate T-cells.

Balance-directed protein engineering of IsPETase enhances both PET hydrolysis activity and thermostability

This study engineers IsPETase to balance PET hydrolysis activity and thermostability, resulting in a variant that outperforms existing variants in depolymerization efficiency.

Combined blockade of VEGF, Angiopoietin-2, and PD1 reprograms glioblastoma endothelial cells into quasi-antigen-presenting cells

This study shows that blocking VEGF, Ang2, and PD1 reprograms GBM endothelial cells into quasi-antigen-presenting cells, enhancing anti-tumor responses and controlling edema.

G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis

This study identifies GPR151 as a regulator of hepatic gluconeogenesis and links its dysfunction to type 2 diabetes risk.

Label-free three-dimensional analyses of live cells with deep-learning-based segmentation exploiting refractive index distributions

The paper develops a label-free 3D segmentation method using deep learning to analyze live cells and their organelles without exogenous labels.

Effects of Platycodon grandiflorum on Gut Microbiota and Immune System of Immunosuppressed Mouse

This study investigates the effects of Platycodon grandiflorum diets on gut microbiota and immune system in immunosuppressed mice, finding increased microbial abundance and immune-related biomarker changes.

Phodopus roborovskii SH101 as a systemic infection model of SARS-CoV-2

This paper identifies a hamster model, Phodopus roborovskii SH101, that exhibits systemic SARS-CoV-2 infection with clinical symptoms similar to human COVID-19.

Differential TM4SF5-mediated SIRT1 modulation and signaling for chronic liver disease

This study identifies TM4SF5's role in modulating SIRT1 and STAT3 signaling during NAFL to NASH progression, showing age-dependent effects and potential therapeutic targets.

Dynamic healing and remodeling of mandibular ramus in segmental mobility and cortical overlap after intraoral vertical osteotomy

This study examines 3D morphological changes in the mandibular ramus after IVRO, showing dynamic remodeling and association with immediate postoperative overlap patterns.