BiophysicsbioRxiv
The N-terminal domain of ALS-linked TDP-43 assembles without misfolding
P. S. Tsoi, K. J. Choi, P. G. Leonard…·A. C. M. Ferreon
This study shows the N-terminal domain of TDP-43 can oligomerize under physiological conditions, potentially promoting pathological aggregation of the C-terminal domain in neurodegenerative diseases.
DOI 10.1002/anie.201706769