Structure-based design of hepatitis C virus E2 glycoprotein improves serum binding and cross-neutralization
B. Pierce, Z.-y. Keck, R. Wang, P. Lau, K. J. Garagusi, K. Elkholy, E. A. Toth, R. A. Urbanowicz, J. D. Guest, P. Agnihotri, M. C. Kerzic, A. Marin, A. K. Andrianov, J. K. Ball, R. Mariuzza, , S. Foung
The paper designs optimized HCV E2 glycoproteins to enhance binding and cross-neutralization by modifying antigenic sites and testing immunogenicity in mice.
bioRxiv · Apr 15, 2020Microbiology