ImmunologybioRxivPreprint
Cooperative binding of TCR and CD4 to pMHC enhances TCR sensitivity
M. N. Rushdi, V. Pan, K. Li…·C. Zhu
The paper shows CD4 enhances TCR sensitivity by forming trimolecular bonds with pMHC, which are stabilized by force and proximity.
DOI 10.1101/2021.11.22.469547