P. Lau

Constitutive Photomorphogenesis Protein 1 homolog (COP1) sustains nuclear factor-4 alpha function in human hepatocyte models

This study shows COP1 maintains HNF4A function in primary hepatocytes and HepG2 cells but not HuH-7 cells, challenging previous links between COP1 and hepatic tumorigenesis.

Water chlorination increases the relative abundance of an antibiotic resistance marker in developing sourdough starters

This study shows that water chlorination increases the abundance of an antibiotic resistance marker in sourdough starters without significantly altering overall bacterial communities.

Regulation of TRIB1 abundance in hepatoma models

This study investigates TRIB1 regulation in hepatoma models, finding that proteasome inhibition increases TRIB1 levels but does not stabilize it, suggesting proteasome-independent degradation and transcriptional regulation as key mechanisms.

A common polymorphism that protects from cardiovascular disease increases fibronectin processing and secretion

The paper identifies a common polymorphism in the FN1 gene that reduces cardiovascular disease risk by altering fibronectin secretion and glycosylation.

Structure-based design of hepatitis C virus E2 glycoprotein improves serum binding and cross-neutralization

The paper designs optimized HCV E2 glycoproteins to enhance binding and cross-neutralization by modifying antigenic sites and testing immunogenicity in mice.

RNA binding kinase UHMK1 regulates therapy induced metabolic adaptation in BRAFV600 melanoma

The paper identifies UHMK1 as a regulator of metabolic adaptation in BRAFV600 melanoma under targeted therapy, showing its role in mRNA transport and translation and its impact on therapy resistance.