Author

K. J. Sutcliffe

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Pharmacology & Toxicology· 1

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Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

E. Kelly· 1 shared G. Henderson· 1 shared R. A. Corey· 1 shared R. B. Sessions· 1 shared S. J. Charlton· 1 shared

Activity by Year

2021-2021 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperPharmacology & Toxicology

E. Kelly

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1 paper

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintFeb 4, 2021

Fentanyl binds to the mu-opioid receptor via the lipid membrane and transmembrane helices

K. J. Sutcliffe, R. A. Corey, S. J. Charlton…·E. Kelly

This study identifies a novel binding mechanism of fentanyl to the mu-opioid receptor involving membrane partitioning and transmembrane helix diffusion, explaining its high potency and resistance to naloxone.

DOI 10.1101/2021.02.04.429703

mechanistic / dynamical model

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