JAK2V617F mutant megakaryocytes contribute to hematopoietic aging in a murine model of myeloproliferative neoplasm
S. Lee, H. Wong, M. Castiglione, M. Murphy, K. Kaushansky, H. Zhan
This study shows that JAK2V617F mutant megakaryocytes accelerate hematopoietic aging by affecting HSC interactions and vascular niche function in a murine MPN model.
bioRxiv · Aug 24, 2021Cancer Biology