M. Murphy

AN UPDATED POPULATION ESTIMATE FOR NORTHERN GANNETS ACROSS THEIR NORTH-EAST ATLANTIC BREEDING RANGE FOLLOWING THE 2022 OUTBREAK OF HIGH PATHOGENICITY AVIAN INFLUENZA

This study updates the population estimate for northern gannets in the North-East Atlantic after a 2022 HPAI outbreak, showing a 17% decline in occupied sites.

NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in Solitary Fibrous Tumors

This study identifies NAB2-STAT6 as a driver of a neuroendocrine program in SFTs through its role in enhancing EGR1 target gene expression.

Deep mutational scanning reveals functional constraints and antigenic variability of Lassa virus glycoprotein complex

Protein thiol alterations drive aberrant phase separation in aging

This study shows that aging-related changes in cysteine posttranslational modifications alter protein phase separation, leading to aggregation and neurodegeneration.

Dissecting components of the Campylobacter jejuni fetMP-fetABCDEF gene cluster in iron scavenging

This study investigates the role of the fetMP-fetABCDEF gene cluster in C. jejuni iron acquisition, showing that fetA-D are essential for growth under iron limitation and that FetE and FetF function redundantly as oxidoreductases.

Antigen spacing on protein nanoparticles influences antibody responses to vaccination

This study shows that antigen spacing on protein nanoparticles affects antibody responses to vaccination, with decreased spacing improving hemagglutination inhibition and neutralization potency.

Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains

This study identifies cryptic transmembrane domains in designed protein nanoparticles that hinder secretion and introduces a computational tool, Degreaser, to remove them while maintaining stability, improving secretion efficiency.

Structural insights into AT-rich DNA recognition by SALL family proteins

The paper presents crystal structures of SALL family proteins bound to AT-rich DNA, revealing their recognition mechanism and functional importance in cell fate control.

JAK2V617F mutant megakaryocytes contribute to hematopoietic aging in a murine model of myeloproliferative neoplasm

This study shows that JAK2V617F mutant megakaryocytes accelerate hematopoietic aging by affecting HSC interactions and vascular niche function in a murine MPN model.

Structure-based design of stabilized recombinant influenza neuraminidase tetramers

This study designs stabilized recombinant influenza neuraminidase tetramers by uncovering structural principles and improving thermal stability and antibody affinity.

Stabilization of the SARS-CoV-2 Spike receptor-binding domain using deep mutational scanning and structure-based design

This paper designs stabilized SARS-CoV-2 RBD variants using deep mutational scanning and structure-based design, showing improved thermal stability and manufacturability for vaccine applications.

A Method for Rapid Flow-cytometric Isolation of Endothelial Nuclei and RNA from Archived Frozen Brain Tissue

This paper develops a method to isolate endothelial nuclei and RNA from archived frozen brain tissues, showing it reliably extracts endothelial RNA and correlates with whole-cell expression.

Effects of BCG vaccination on donor unrestricted T cells in humans

This study examines the effects of BCG vaccination on donor unrestricted T (DURT) cells in humans, finding increased frequencies of certain T cell subsets in infants but no changes in others.

Tracking of Anopheles stephensi in Ethiopia using mitochondrial DNA reveals pattern of spread

This study tracks the spread of Anopheles stephensi in Ethiopia using mitochondrial DNA, revealing a South Asian origin and recent expansion into southeastern regions with multiple introductions.

Rapid evolutionary turnover of mobile genetic elements drives microbial resistance to viruses

The paper shows that mobile genetic elements rapidly evolve to confer phage resistance in bacteria, with resistance unlinked to other genomic features.

Adjuvanting a subunit SARS-CoV-2 nanoparticle vaccine to induce protective immunity in non-human primates

This study evaluates adjuvants for a subunit SARS-CoV-2 nanoparticle vaccine in non-human primates, showing durable neutralizing antibody responses and protection against infection.

Structured decomposition improves systems serology prediction and interpretation

This paper introduces TMTF, a tensor factorization method that improves data reduction, prediction, and interpretation in systems serology by capturing structured patterns in HIV humoral immune responses.

Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2

This study designs SARS-CoV-2 nanoparticle vaccines that induce strong neutralizing antibodies in mice, with higher titers and lower doses than existing trimer vaccines.

Elicitation of broadly protective immunity to influenza by multivalent hemagglutinin nanoparticle vaccines

Nanoparticle immunogens with four seasonal influenza hemagglutinins elicit neutralizing antibodies against both the head and stem, providing broad protection against diverse influenza strains.

Protocol and reagents for pseudotyping lentiviral particles with SARS-CoV-2 Spike protein for neutralization assays

This paper provides a protocol for pseudotyping lentiviral particles with SARS-CoV-2 Spike protein to measure neutralizing antibody activity in a luciferase-based assay.

Anopheles stephensi as an emerging malaria vector in the Horn of Africa with high susceptibility to Ethiopian Plasmodium vivax and Plasmodium falciparum isolates

The paper assesses the susceptibility of Anopheles stephensi to Ethiopian Plasmodium vivax and P. falciparum isolates, finding high receptivity and potential for increased malaria transmission in the Horn of Africa.

Geographical distribution of Anopheles stephensi in eastern Ethiopia

The paper surveys Anopheles stephensi distribution in eastern Ethiopia using morphological and molecular methods, confirming its presence and co-occurrence with Aedes aegypti in larval habitats.

FLASH: A next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences

FLASH is a CRISPR-based diagnostic method that enhances detection of low-abundance antimicrobial resistance sequences in metagenomic data.

Sulforaphane Alters the Acidification of the Vacuole to Trigger Cell Death

This study identifies that sulforaphane induces cell death in yeast by altering vacuolar acidification, and shows similar effects in human lung cancer cells.

A Framework for Predicting Design Failures in Engineered Genetic Codes

The paper develops a machine learning framework to predict genetic code design failures by analyzing codon usage effects on E. coli viability.