Author

K. Kugou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

H. Kogashi· 2 shared K. Nakatani· 2 shared Y. Hasegawa· 2 shared Y. Hippo· 2 shared Y. Suenaga· 2 shared E. Furukawa· 1 shared E. Kita· 1 shared J. Lin· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

H. Kogashi

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2 papers

Recent·Most cited

Inhibition of OCT4 Binding at the MYCN Locus Induces Neuroblastoma Cell Death Accompanied by Downregulation of Transcripts with High-Open Reading Frame Dominance

K. Nakatani, H. Kogashi, T. Miyamoto, T. Setoguchi, T. Sakuma, K. Kugou, Y. Hasegawa, T. Yamamoto, Y. Hippo, Y. Suenaga

This study shows that inhibiting OCT4 binding at the MYCN locus in neuroblastoma cells reduces MYCN activity, leading to cell death through caspase-2 activation and downregulation of high-ORF dominance transcripts.

bioRxiv · Jun 8, 2023 · PreprintCancer Biology

Global changes in open reading frame dominance of RNAs during cancer initiation and progression

Y. Suenaga, H. Kogashi, K. Nakatani, J. Lin, Y. Hasegawa, K. Kugou, Y. Kawashima, E. Furukawa, K. Okumura, E. Kita, Y. Wakabayashi, M. Kato, M. Kawazu, Y. Hippo

The paper measures ORF dominance in cancer and finds it increases with carcinogenesis, correlates with translation, and blurs coding/noncoding boundaries before metastasis.

bioRxiv · Jun 2, 2023 · PreprintCancer Biology