T. Yamamoto

This study investigates how different regions of the rodent medial agranular cortex affect unilateral spatial neglect severity and recovery.

This study shows UGGT1 reglucosylation competes with EDEM-mediated degradation of misfolded glycoproteins, influencing ER protein quality control.

This study investigates how molecular chirality leads to cellular chirality in epithelial cells, revealing that concentric actomyosin filaments drive intracellular rotation.

This study evaluates antibody and cellular immune responses in kidney transplant recipients after three mRNA vaccine doses, finding lower neutralizing titers and T cell responses compared to healthy controls.

This study shows that inhibiting OCT4 binding at the MYCN locus in neuroblastoma cells reduces MYCN activity, leading to cell death through caspase-2 activation and downregulation of high-ORF dominance transcripts.

The paper identifies how NEAT1 domains specify shell protein composition in paraspeckles, enabling their independence from nuclear speckles through phase separation.

This study evaluates the safety and immune response of a sublingual SARS-CoV-2 vaccine with RBD antigen and Poly(I:C) or AddaS03 adjuvant in non-human primates, finding Poly(I:C) induces a balanced immune response.

This study investigates how gibberellin (GA) affects Bletilla striata seed germination and mycorrhizal symbiosis, revealing that GA inactivation enables auto-activation of the symbiosis pathway.

The paper develops a scaling theory for polymer brushes inspired by ribosomal RNA transcription, showing how polymerization rate affects monomer diffusion and volume fraction.

This study identifies PFKFB3 as a key regulator of glycolytic metabolism in HSCs under stress, showing its context-dependent activation promotes ATP production and hematopoiesis.

The paper develops a theory explaining how tandemly repeated genes in fission yeast contribute to heterochromatin assembly through small RNA production and histone methylation.

This study shows that tetraploid cells are more sensitive to CENP-E inhibitors than diploid cells, leading to selective growth suppression through mitotic delay and cohesion fatigue.

This paper introduces Frame Editors (FEs) that improve CRISPR-Cas9 editing accuracy by inducing controlled frameshifts without templates, reducing random mutations and off-target effects.

The paper constructs a theoretical model to explain the formation of a unique bean-shaped structure formed by mutant condensin complexes and nucleosomes in Xenopus egg extracts.

A low carbohydrate diet suppresses neuroendocrine tumor onset and progression by reducing insulin signaling and PI3K-Akt-mTOR pathway activity in mouse models and correlates with better prognosis in patients.

This study evaluates a sublingual SARS-CoV-2 vaccine with RBD antigen and poly(I:C) adjuvant in cynomolgus macaques, showing mucosal and systemic immune responses without allergic reactions.

This study investigates reinfection with SARS-CoV-2 Omicron variants in previously infected hamsters, finding that immunity prevents pneumonia but allows viral replication in the upper airways with increased mutation diversity.

The paper compares self-recruitment and larval dispersal between a semi-enclosed bay and an open coast, finding that stronger cross-shore currents in the bay reduce local retention and self-recruitment.

This study identifies miR-891b and PSAT1 as regulators of EV secretion and cancer progression through the serine-ceramide pathway.

This study uses hit-and-run silencing to suppress DUX4 in FSHD patient-derived iPSCs by targeting DNA hypomethylation on D4Z4 repeats, achieving sustained suppression for at least two weeks.

This study applies Bcl-6/Bcl-xL retroviral transduction to isolate antibodies and generate B cell clones from various B cell populations in healthy and infected individuals.

The paper develops a theory explaining how loop extrusion by condensin drives a volume phase transition in entangled chromosomes, leading to their collapse.

The paper compares the efficacy of neutralizing antibodies and antiviral drugs against SARS-CoV-2 Omicron subvariants BA.1 and BA.2, finding differential responses to specific treatments.

This paper develops CRISPR/Cas9 and Cre/loxP systems to efficiently generate multiple knockout mutants in Colletotrichum orbiculare and identifies functional sugar transporters.

This study shows naked mole-rats (NMRs) resist chemical carcinogenesis through reduced inflammatory responses linked to necroptosis deficiency.

This paper investigates 3D-printed PMMA/ceramic composites with antibacterial properties, finding that aluminum nitride provides the best dispersion and antibacterial effect against E. coli.

The paper develops a theoretical model explaining how nascent pre-rRNAs suppress fibrillar center growth in nucleoli through lateral pressure, supported by experimental validation.

The paper uses graph neural networks to infer cell coordination rules from live tissue data, revealing region-specific coordination patterns in mammalian epidermis.

This study identifies a 3D matrix adhesion complex involving β-PIX and Myo18A that drives invasive cell migration by coupling nuclear force transmission to protrusion dynamics.

This study shows adenosine enhances IL-17A secretion by Th17 cells via A2aR, promoting neutrophilic inflammation and suggesting A2aR antagonists as potential treatments for Th17-related autoimmune diseases.