Author

K. L. Cook

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. Westwood· 3 shared A. S. Wilson· 2 shared D. R. Soto-Pantoja· 2 shared E. R. Stirling· 2 shared G. J. Lesser· 2 shared A. J. Wilson· 1 shared A. Thomas· 1 shared B. A. Kerr· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersCancer Biology

B. Westwood

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Author profile →

3 papers

Recent·Most cited

Anti-CD47 immunotherapy as a therapeutic strategy for the treatment of breast cancer brain metastasis

J. D. Mackert, E. R. Stirling, A. S. Wilson, B. Westwood, D. Zhao, H.-W. Lo, L. J. Metheny-Barlow, K. L. Cook, G. J. Lesser, D. R. Soto-Pantoja

This study shows that blocking CD47 reduces brain metastasis in breast cancer by enhancing immune response and altering tumor microenvironment signaling.

bioRxiv · Jul 25, 2023 · PreprintCancer Biology

Absence of CD47 in the tumor microenvironment modulates tumor metabolism and immunosuppressive signatures limiting breast cancer progression.

E. R. Stirling, Y.-T. Tsai, S. M. Bronson, A. J. Wilson, B. Westwood, A. Thomas, P. L. Triozzi, C. M. Furdui, G. J. Lesser, K. L. Cook, D. R. Soto-Pantoja

This paper shows that CD47 absence in tumors reduces tumor burden and enhances immune response by altering metabolism and immunosuppressive signatures in breast cancer.

bioRxiv · Jul 12, 2023 · PreprintCancer Biology

A Novel Model of Estrogen Receptor-Positive Breast Cancer Bone Metastasis with Antiestrogen Responsiveness

K. L. Langsten, L. Shi, A. S. Wilson, B. Westwood, M. T. Xie, V. E. Surratt, J. Turner, R. Singh, K. L. Cook, B. A. Kerr

This paper develops an immunocompetent ER+ breast cancer mouse model with spontaneous bone metastasis and antiestrogen responsiveness, showing treatment efficacy with tamoxifen and fulvestrant.

bioRxiv · Sep 16, 2021 · PreprintCancer Biology