Phytochemical Nrf2 activator attenuates skeletal muscle mitochondrial dysfunction and impaired proteostasis in a preclinical model of musculoskeletal aging
R. V. Musci, K. M. Andrie, M. A. Walsh, Z. J. Valenti, M. F. Afzali, T. E. Johnson, T. E. Kail, R. Martinez, T. Nguyen, J. L. Sanford, M. D. Murrell, J. M. McCord, B. M. Hybertson, B. F. Miller, Q. Zhang, , K. L. Hamilton
This study shows that a Nrf2 activator improves mitochondrial function and proteostasis in aging guinea pigs but does not significantly enhance mobility.
bioRxiv · Jun 11, 2021 · PreprintPhysiology