Author

P. Verkade

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Immunology· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Assay:electronic health records· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2

Frequent Co-Authors

J. Mantell· 3 shared U. Borucu· 3 shared D. M. Paul· 2 shared R. F. Murphy· 2 shared X. Ruan· 2 shared A. Blocker· 1 shared A. C. Gill· 1 shared A. D. Davidson· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersCell Biology

J. Mantell

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

CryoET reveals actin filaments within platelet microtubules

C. Tsuji, M. Bradshaw, M. Allen, M. L. Jackson, J. Mantell, U. Borucu, A. W. Poole, P. Verkade, I. Hers, D. M. Paul, M. Dodding

The paper uses cryoET to show cofilin-bound F-actin within platelet microtubules, revealing physiological actin-microtubule hybrids formed under mechanical stress.

bioRxiv · Nov 24, 2023Cell Biology

Five inhibitory receptors display distinct vesicular distributions in T cells

J. Lu, A. Veler, B. Simonetti, T. Raj, P. H. Chou, S. J. Cross, A. M. Phillips, X. Ruan, L. Huynh, A. W. Dowsey, D. Ye, R. F. Murphy, P. Verkade, P. J. Cullen, C. Wuelfing

The paper characterizes the subcellular distributions of five inhibitory receptors in T cells and finds they are distinct, with CTLA-4 preferentially associating with lysosomal-derived vesicles.

bioRxiv · Jul 21, 2023Immunology

TECPR1 provides E3-ligase like activity to the ATG5-ATG12 complex to conjugate LC3/ATG8 to damaged lysosomes

Y. Wang, M. Jefferson, J. Mccoll, P. Verkade, U. Mayer, T. Wileman

This study shows TECPR1 can substitute for ATG16L1 to conjugate LC3 to damaged lysosomes by providing E3-ligase activity to the ATG5-ATG12 complex.

bioRxiv · Jun 24, 2023 · PreprintCell Biology

The Free Fatty Acid-Binding Pocket is a Conserved Hallmark in Pathogenic β-Coronavirus Spike Proteins from SARS-CoV to Omicron

C. Toelzer, K. Gupta, S. K. N. Yadav, L. Hodgson, M. Kavanagh Williamson, D. Buzas, U. Borucu, K. Powers, R. Stenner, K. Vasileiou, F. Garzoni, D. Fitzgerald, C. Payre, G. Lambeau, A. D. Davidson, , C. Schaffitzel

The paper identifies a conserved free fatty acid-binding pocket in pathogenic β-coronavirus spike proteins that suppresses viral infection and replication.

bioRxiv · Apr 22, 2022Biochemistry

Bacterial flagella disrupt host cell membranes and interact with cytoskeletal components

E. B. Wolfson, J. Elvidge, A. Tahoun, T. Gillespie, J. Mantell, S. P. McAteer, Y. Rossez, E. Paxton, F. Lane, D. J. Shaw, A. C. Gill, J. Steveni, P. Verkade, A. Blocker, A. Mahajan, D. L. Gally

This study investigates how bacterial flagella from E. coli and Salmonella species interact with host cell membranes and cytoskeletal components, showing membrane disruption and actin polymerization effects.

bioRxiv · Feb 12, 2020 · PreprintMicrobiology

Membrane insertion of chromogranin B for granule maturation in regulated secretion

G. Yadav, H. Wang, J. Ouwendijk, M. Annamalai, S. Cross, Q. Wang, D. W. Hagan, C. Mathews, E. Phelps, P. Verkade, M. X. Zhu, Q.-X. Jiang

This paper identifies chromogranin B (CHGB) as the anion channel essential for secretory granule maturation and acidification in regulated secretion.

bioRxiv · Dec 28, 2019 · PreprintCell Biology

In situ cryo-electron tomography reveals filamentous actin within the microtubule lumen

D. M. Paul, J. Mantell, U. Borucu, J. Coombs, K. J. Surridge, J. M. Squire, P. Verkade, M. P. Dodding

The paper uses cryo-electron tomography to show F-actin within microtubule lumens in induced cellular projections, revealing new cytoskeletal configurations.

bioRxiv · Nov 18, 2019Cell Biology

Transient protein accumulation at the center of the T cell antigen presenting cell interface drives efficient IL-2 secretion

D. J. Clark, L. E. McMillan, S. L. Tan, G. Bellomo, C. Massoue, H. Thompson, L. Mykhaylechko, D. Alibhai, X. Ruan, K. L. Singleton, M. Du, A. J. Hedges, P. L. Schwartzberg, P. Verkade, R. F. Murphy, C. Wülfing

The paper investigates the role of the central supramolecular signaling cluster (cSMAC) in T cell activation by manipulating adaptor proteins and showing its impact on IL-2 secretion.

bioRxiv · Feb 4, 2019Immunology