Author

R. F. Murphy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Assay:imaging· 1

Frequent Co-Authors

X. Ruan· 3 shared P. Verkade· 2 shared A. J. Hedges· 1 shared A. M. Phillips· 1 shared A. Veler· 1 shared A. W. Dowsey· 1 shared B. Simonetti· 1 shared C. Massoue· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

X. Ruan

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Five inhibitory receptors display distinct vesicular distributions in T cells

J. Lu, A. Veler, B. Simonetti, T. Raj, P. H. Chou, S. J. Cross, A. M. Phillips, X. Ruan, L. Huynh, A. W. Dowsey, D. Ye, R. F. Murphy, P. Verkade, P. J. Cullen, C. Wuelfing

The paper characterizes the subcellular distributions of five inhibitory receptors in T cells and finds they are distinct, with CTLA-4 preferentially associating with lysosomal-derived vesicles.

bioRxiv · Jul 21, 2023Immunology

Transient protein accumulation at the center of the T cell antigen presenting cell interface drives efficient IL-2 secretion

D. J. Clark, L. E. McMillan, S. L. Tan, G. Bellomo, C. Massoue, H. Thompson, L. Mykhaylechko, D. Alibhai, X. Ruan, K. L. Singleton, M. Du, A. J. Hedges, P. L. Schwartzberg, P. Verkade, R. F. Murphy, C. Wülfing

The paper investigates the role of the central supramolecular signaling cluster (cSMAC) in T cell activation by manipulating adaptor proteins and showing its impact on IL-2 secretion.

bioRxiv · Feb 4, 2019Immunology

Image-derived Models of Cell Organization Changes During Differentiation of PC12 Cells

X. Ruan, G. R. Johnson, I. Bierschenk, R. Nitschke, M. Boerries, H. Busch, R. F. Murphy

The paper develops a generative model to track cell organization changes during PC12 differentiation using static images and shape analysis.

bioRxiv · Jan 16, 2019 · PreprintCell Biology