X. Ruan

Stimulation of saliva affects the release of aroma in wine; a study of microbiota, biochemistry and participant origin

This study examines how saliva stimulation and participant origin affect aroma release from wine by analyzing salivary composition and microbial interactions.

BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor

This study shows that FHD-286, a BRG1/BRM inhibitor, reduces AML burden and improves survival when combined with Menin or BET inhibitors in xenograft models of AML with MLL1r or mtNPM1.

Five inhibitory receptors display distinct vesicular distributions in T cells

The paper characterizes the subcellular distributions of five inhibitory receptors in T cells and finds they are distinct, with CTLA-4 preferentially associating with lysosomal-derived vesicles.

Characterization, Comparison, and Optimization of Lattice Light Sheets

This paper compares and optimizes lattice light sheets to improve resolution and reduce photobleaching in light sheet microscopy.

Variation of wine preference amongst consumers is influenced by the composition of salivary proteins

The study shows that differences in salivary protein composition between Western and Chinese wine tasters influence their perception and preference for wine flavors.

The salivary microbiome shows a high prevalence of core bacterial members yet variability across human populations

This study identifies a core salivary microbiome across human populations using 16S rRNA sequencing, showing stability and variability influenced by geographic location and diet.

Multi-omics consensus ensemble refines the classification of muscle-invasive bladder cancer with stratified prognosis, tumour microenvironment and distinct sensitivity to frontline therapies

This paper refines muscle-invasive bladder cancer classification using multi-omics data, identifying four subtypes with distinct prognoses and therapeutic responses.

CPEB2 m6A Methylation Regulates BTB Permeability via Affecting Splicing Factor SRSF5 Stability

This study identifies a regulatory pathway involving CPEB2 m6A methylation that affects BTB permeability through SRSF5 and P51-ETS1, enhancing drug efficacy in glioma treatment.

Surgery and Radioactive Iodine Therapeutic Strategy for Patients Greater than 60 Years of Age with Differentiated Thyroid Cancer

This study evaluates cause-specific survival in elderly differentiated thyroid cancer patients comparing surgical treatment vs. non-surgical management and the impact of RAI-131 therapy.

Multilevel integrative transcriptome analyses in humans and humanized mice define in vivo human lncRNA metabolic regulators

This study identifies human lncRNA metabolic regulators (hLMRs) using integrative transcriptome analyses and humanized mouse models, validating one hLMR's role in cholesterol metabolism.

Transient protein accumulation at the center of the T cell antigen presenting cell interface drives efficient IL-2 secretion

The paper investigates the role of the central supramolecular signaling cluster (cSMAC) in T cell activation by manipulating adaptor proteins and showing its impact on IL-2 secretion.

Image-derived Models of Cell Organization Changes During Differentiation of PC12 Cells

The paper develops a generative model to track cell organization changes during PC12 differentiation using static images and shape analysis.

Temperature dependence of allelopathy duality and its influence on boreal forest succession-A case analysis of Picea schrenkiana

This paper investigates the temperature-dependent duality of DHAP allelopathy in Picea schrenkiana, showing how its effects shift from promotion to inhibition with temperature changes, influencing forest succession.