Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the Integrated Stress Response
Y. Yan, M. Shetty, H. P. Harding, G. George, A. Zyryanova, K. Labbe, A. Mafi, Q. Hao, C. Sidrauski, D. Ron
The paper identifies a mechanism by which eIF2γ binding to PPP1R15A enhances catalytic efficiency of the holophosphatase that terminates the integrated stress response.
bioRxiv · Dec 15, 2023Biochemistry